Christer Betsholtz
Christer Betsholtz (born July 11, 1959 in Stockholm ) is a Swedish pathologist and biochemist (vascular biology).
Betsholtz obtained his undergraduate degree in medicine in 1981 and received his doctorate in pathology from Uppsala University in 1986 . He was then a lecturer in experimental pathology and from 1989 to 1993 research professor (Särskild Forskartjänst) of the Swedish Research Council and the Swedish Cancer Research Society (Cancer Foundation). In 1993 he became Professor of Medicinal and Physiological Chemistry at the University of Gothenburg and in 2004 Professor of Vascular Biology at the Karolinska Institute . He is a professor at Uppsala University and at the Karolinska Institute in Stockholm, where he became Director of the Integrated Cardio Metabolic Center (ICMC) in 2016. He is also a senior scientist at AstraZeneca , who co-founded the ICMC in 2013.
He deals with angiogenesis (e.g. mode of action of the vascular endothelial growth factor ) and the role of pericytes in holding blood vessels together. In 2000 he was involved in the discovery of PDGF -C and examined the effects of other PDGF.
In 2018 he received the Louis Jeantet Prize .
He is a member of the Academia Europaea (2004) and the European Molecular Biology Organization (EMBO). In 2007 he became a member of the Royal Swedish Academy of Sciences. In 2012 he received an ERC Advanced Grant. From 2009 to 2013 he was Söderberg Professor of Medicine and in 2010 he received the Axel Hirsch Prize of the Karolinska Institute. In 2006 he became a member of the Nobel Assembly at the Karolinska Institute and from 2007 to 2010 he was an adjunct member of the Nobel Committee.
Fonts (selection)
- with P. Levéen a. a .: Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities, Genes & development, Volume 8, 1994, pp. 1875-1887
- with P. Lindahl, BR Johansson, P. Levéen: Pericyte loss and microaneurysm formation in PDGF-B-deficient mice, Science, Volume 277, 1997, pp. 242-245
- with M. Hellstrom, P. Lindahl, A. Abramsson: Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse, Development, Volume 126, 1999, p. 3047 -3055
- with M. Hellström a. a .: Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis, Journal of Cell Biology, Volume 153, 2001, pp. 543-554
- with H. Gerhardt u. a .: VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia, Journal of Cell Biology, Volume 161, 2003, pp. 1163-1177
- with H. Gerhardt: Endothelial-pericyte interactions in angiogenesis, Cell and tissue research, Volume 314, 2003, pp. 15-23
- with MJ Karkkainen a. a .: Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins, Nature Immunology , Volume 5, 2004, pp. 74-80
- with A. Armulik, A. Abramsson: Endothelial / pericyte interactions, Circulation research, Volume 97, 2005, pp. 512-523
- with M. Hellström a. a .: Dll4 signaling through Notch1 regulates formation of tip cells during angiogenesis, Nature, Volume 445, 2007, pp. 776-780
- with J. Andrade, R. Gallini: Role of platelet-derived growth factors in physiology and medicine, Genes & development, Volume 22, 2008, No. 10, pp. 1276-1312
- with A. Armulik u. a .: Pericytes regulate the blood-brain barrier, Nature, Volume 468, 2010, pp. 557-561
- with A. Armulik, G. Genové: Pericytes: developmental, physiological, and pathological perspectives, problems, and promises, Developmental cell, Volume 21, 2011, pp. 193-215
Web links
Individual evidence
| personal data | |
|---|---|
| SURNAME | Betsholtz, Christer |
| BRIEF DESCRIPTION | Swedish pathologist and biochemist |
| DATE OF BIRTH | July 11, 1959 |
| PLACE OF BIRTH | Stockholm |