Common Toxicity Criteria
The Common Toxicity Criteria ( CTC ; German General Toxicity Criteria ) is a systematic classification of adverse events .
The newer name is Common Terminology Criteria of Adverse Events ( CTCAE ; German General Terminology Criteria of Adverse Events ). From grade 3 onwards one speaks of serious adverse events . The table shows some examples.
| criteria | Grade 0 |
Grade 1 mild |
Grade 2 moderate |
Grade 3 severe |
Grade 4 life threatening |
Grade 5 death |
|---|---|---|---|---|---|---|
| Neutrophils | ≥2.0 x 10 9 / dm³ | (1.5 ... <2.0) · 10 9 / dm³ | (1.0 ... <1.5) · 10 9 / dm³ | (0.5 ... <1.0) · 10 9 / dm³ | <0.5 x 10 9 / dm³ | - |
| Platelets | ≥100,000 / µl | (75,000 ... 99,999) / µl | (50,000 ... 74,999) / µl | (25,000 ... 49,999) / µl | <25,000 / µl | - |
| nausea | no nausea | something, food intake not restricted | moderate, food intake restricted | strong, no food intake | - | - |
| Vomit | no vomiting | 1-2x / d | 3-5x / d | ≥6 x / d | life threatening | - |
| diarrhea | no diarrhea | (2… 3) x / d | (3… 6) x / d or moderate cramps | (7… 9) x / d or severe convulsions, incontinence | > 9x / d or bloody | - |
| Stomatitis | no stomatitis | Erythema , painless erosions | Ulcers , solid food possible | Ulcers , liquid food | no food intake possible | - |
| Hair loss | no hair loss | mild hair loss | pronounced hair loss | - | - | - |
