Csaba Horváth (chemical engineer)

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Csaba Horvath Memorial Award

Csaba Gyula Horváth (born January 25, 1930 in Szolnok , Hungary , † April 13, 2004 in New Haven (Connecticut) ) was a Hungarian-American chemical engineer.

Horváth studied chemical engineering at the TU Budapest . In 1956, like many other Hungarians, he went to the West after the uprising and worked for Hoechst AG and studied physical chemistry at the University of Frankfurt with his doctorate in 1963. From 1964 he was at Yale University , first in the School of Medicine and from 1972 in the chemical engineering department, where he received a full professorship in 1979 and was head of the department from 1987 to 1993. In 1998 he became Roberto Goiuzeta Professor of Chemical Engineering. He died of a stroke in 2004.

In 1967 Horváth developed the first modern apparatus for high-performance liquid chromatography (HPLC). Stationary phases made of very fine powder were used and the samples were pressed through the columns under high pressure with the help of mechanical pumps. In the 1970s Horváth combined HPLC with the technique of reversed phase chromatography (RPC or RPLC), which was then often used in HPLC, especially in biochemistry. The stationary phase is hydrophobic, the mobile polar phase is a mixture of water and solvent. Reverse phase chromatography was developed in 1950 by Archer JP Martin and GA Howard in England. Reversal alludes to the fact that a solid polar stationary phase was used previously and a less polar solvent was used in the mobile phase.

Horvath developed the method primarily for the separation of biological molecules such as proteins and also worked on other separation methods ( electrophoresis , displacement chromatography).

Further HPLC pioneers were the Austrian chemist Josef Franz Karl Huber (1925-2000) and the American chemist John Calvin Giddings (1930-1996) as well as Joseph Jack Kirkland (* 1925) in the development of stationary phases and Sidney Pestka in the reverse phase .

A young talent award at the HPLC meeting is named in his honor. He was a member of the National Academy of Engineering . In 2003 he received the Torbern Bergman Medal from the Swedish Chemical Society .

He had been married to the Italian Valeria Scioscioli since 1963, with whom he had two daughters.

literature

  • I. Molnár: Searching for Robust HPLC Methods - Csaba Horváth and the Solvophobic Theory , Chromatographia, Volume 62, Suppl. 13, 2005, s1-s17
  • Andras Guttman: Obituary: Professor Csaba Horváth (1930-2004), Electrophoresis, Volume 25, 2004, pp. 3067-3068
  • Günther Bonn: Obituary: Professor Csaba Horváth (1930-2004) , Proteomics, Volume 4, 2004, pp. 1855-1856

Web links

Individual evidence

  1. ↑ Derek Lowe, Das Chemiebuch, Librero 2017, p. 426
  2. ↑ Lista mottagare. Svenska Kemisamfundet, accessed on September 7, 2019 .
personal data
SURNAME Horváth, Csaba
ALTERNATIVE NAMES Horváth, Csaba Gyula (full name)
BRIEF DESCRIPTION Hungarian-American chemical engineer
DATE OF BIRTH January 25, 1930
PLACE OF BIRTH Szolnok
DATE OF DEATH April 13, 2004
Place of death New Haven (Connecticut)