Denis Noble
Denis Noble (born November 16, 1936 ) is a British physiologist. He is one of the pioneers in systems biology .
Denis Noble studied at University College London , where he received his doctorate in 1961. In his widely acclaimed doctoral thesis, which resulted in two articles in Nature , he developed the first mathematical model of the working heart . Noble held the Burdon Sanderson Chair in Cardiovascular Physiology at Oxford University from 1984 to 2004 . Today he is emeritus and co-director of Computational Physiology in Oxford. As Secretary General of the International Union of Physiological Sciences (IUPS), he was one of the initiators of the Physiom project, in which the interpretation of genome data was to be promoted by setting up quantitative models and solving them through computer simulations .
In 2006 he published The Music of Life, the first popular science book on systems biology. In it he criticizes the ideas of genetic determinism and reductionism , as he finds them most radical in some adherents of Dawkins ' theory of the selfish gene . He puts forward the thesis that due to various feedback mechanisms (e.g. splicing , epigenetics ) the genome is not an organizational level to be emphasized, not a program from which the function of "higher" levels such as proteins, cells or even organs is derived in a reductionist approach could be. Instead, he suggests a systemic approach to organisms.
Fonts
- Initiation of the Heartbeat , 1975
- Electric Current Flow in Excitable Cells , 1975
- Electrophysiology of Single Cardiac Cells , 1987
- Goals, No Goals and Own Goals , 1989
- Sodium-Calcium Exchange , 1989
- Ionic Channels and the Effect of Taurine on the Heart , 1993
- The Logic of Life , 1993
- The Music of Life , 2006
- Dance to the Tune of Life. Biological Relativity , 2016
Web links
| personal data | |
|---|---|
| SURNAME | Noble, Denis |
| BRIEF DESCRIPTION | British physiologist |
| DATE OF BIRTH | November 16, 1936 |