Detlef Zillikens

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Detlef Zillikens (born July 15, 1958 in Wesseling ) is a German dermatologist , university professor and director of the Clinic for Dermatology, Allergology and Venereology at the University Medical Center Schleswig-Holstein , Lübeck campus. He is known for his research on various autoimmune blistering dermatoses such as pemphigus , pemphigoid diseases and dermatitis herpetiformis Duhring .

Life

Zillikens studied human medicine at the Universities of Bonn and Heidelberg and at the University of Illinois in Champaign-Urbana, USA . After two years of surgical training, he worked from 1988 to 1992 as a research assistant at the University Dermatology Clinic in Würzburg, where he became senior physician in 1992. In 1993 he completed his habilitation in dermatology and venereology at the Medical Faculty of the University of Würzburg on the subject of "Cellular and humoral immune mechanisms in the pathogenesis of bullous pemphigoid and pemphigus ". From 1994 to 1997 he worked as an assistant professor at the Department of Biochemistry and in the research laboratory of the Department of Dermatology at the Medical College of Wisconsin in Milwaukee . In 1997 he resumed his work as a senior physician at the University Dermatology Clinic in Würzburg. In 2000 he was appointed adjunct professor. In 2002 he was appointed University Professor of Dermatology and Venereology at the University Dermatology Clinic in Würzburg. Zillikens has been a university professor and director of the Department of Dermatology, Allergology and Venereology at the University Medical Center Schleswig-Holstein, Lübeck campus since 2004, and has been Vice President for Research at the University of Lübeck and chairman of the research committee of the Medical Faculty since 2013.

2004 Zillikens received by the Statutory Health Insurance Physicians Schleswig-Holstein personal appropriations for testing for the presence of autoantibodies in the serum and in the skin of patients with autoimmune bullous diseases, in pemphigus, bullous pemphigoid , Schwangerschaftspemphigoid, mucous membrane , linear IgA dermatosis , epidermolysis bullosa acquisita and dermatitis herpetiformis Duhring .

Scientific contribution

During his residency at the Dermatology Clinic in Würzburg, Zillikens' scientific work focused on the pathogenesis of autoimmune bullous diseases of the skin. Zilliken's investigations during his research stay in the USA led to the characterization of an immunodominant segment on one of the common autoantigens in autoimmune bullous dermatoses (type XVII collagen / BP180) and laid the basis for the development of an ELISA for the detection of autoantibodies in patients with pemphigoid diseases. After his return to Germany, his working group succeeded in establishing new and previously unique animal models for autoimmune bullous dermatoses, first in Würzburg and later in Lübeck, with which the clinical and immunopathological changes in the patients could be simulated. In 2007 Zillikens was a founding member of the Cluster of Excellence "Inflammation at Interfaces". Research into autoimmune blistering dermatoses is an essential contribution of the Lübeck campus to this cluster of excellence. In 2016, Zillikens joined forces with other scientists working on the topic of "Inflammation of the Skin" at the Lübeck campus to form the Center for Research on Inflammation of The Skin (CRIS) . The approximately 140 scientists at this center conduct research on chronic inflammatory skin diseases, in particular pemphigoid diseases, ANCA-associated vasculitis and systemic scleroderma, using modern technologies.

In his translational work , based on a patent, among other things, Zillikens contributed to the development of new test methods for the detection of autoantibodies in patients with autoimmune bullous dermatoses.

Memberships in scientific associations

Zillikens has been an elected member of the German Research Foundation's Medical Review Board since 2012 . Here he works in the "Inflammation Medicine" section and since 2016 also in the ad hoc commission for research groups, clinical research groups and Reinhart Koselleck projects. Zillikens works in several research alliances funded by the German Research Foundation. He is a founding member of the Cluster of Excellence 306 “Inflammation at Interfaces” and has been a member of the Executive Board since its funding in 2007. Since 2011 he has also been the spokesman for the Graduate School 1727 "Modulation of Autoimmunity" and since 2015 the spokesman for the translational Clinical Research Group 303 "Pemphigoid Diseases - Molecular Mechanisms and their Therapeutic Influence". Zillikens is a member of numerous national and international scientific associations.

honors and awards

In 2012 Zillikens was made an international honorary member by the American Dermatological Association , and in 2015 he was appointed Adjunct Visiting Professor of Kasturba Medical College, Manipal University, India.

Publications

Publication list pubmed

Individual evidence

  1. ↑ a b Clinic for Dermatology, Allergology and Venereology (Dermatology Clinic). University Medical Center Schleswig-Holstein, accessed on March 4, 2017 .
  2. ↑ Curriculum Vitae. europass, European Medicines Agency, accessed March 4, 2017 .
  3. ↑ Zillikens D, Rose PR, Balding SD, Liu Z, Olague-Marchan M, Diaz LA, Giudice GJ. Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies. J Invest Dermatol 1997; 109: 573-579.
  4. ↑ Zillikens D, Mascaro JM, Rose PR, Liu Z, Ewing SM, Caux F, Hoffmann RG, Diaz LA, Giudice GJ. A highly sensitive enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoid. J Invest Dermatol 1997; 109: 679-683.
  5. ↑ Sitaru C, Mihai S, Otto C, Chiriac MT, Haußer I, Dotter Weich B, Saito H, Rose C, Ishiko A, and Zillikens D. Induction of dermal-epidermal separation in mice by passive transfer of antibodies to type VII collagen. J Clin Invest 2005; 115: 870-878.
  6. ↑ Sitaru C, Chiriac MT, Mihai S, Büning J, Gebert A, Ishiko A, Zillikens D. Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice. J Immunol 2006; 177: 3461-3468.
  7. ↑ Hirose M, Recke A, Beckmann T, Shimizu A, Ishiko A, Bieber K, Westermann J, Zillikens D, Schmidt E, Ludwig RJ. Repetitive immunization breaks tolerance to type XVII collagen and leads to bullous pemphigoid in mice. J Immunol 2011; 187: 1176-83.
  8. ↑ Schulze FS, Beckmann T, Nimmerjahn F, Ishiko A, Collin M, Koehl J, Goletz S, Zillikens D, Ludwig R, Schmidt E. FcyRIII and FcyRIV mediate tissue destruction in a novel adult mouse model of bullous pemphigoid. On J Pathol 2014; 148: 2185-96.
  9. ↑ Heppe N, Tofern S, Schulze F, Ishiko A, Sina C, Zillikens D, Köhl J, Goletz S, Schmidt E. Experimental murine anit-laminin 332 mucous membrane pemphigoid reflecting clinical and immunopathological characteristics of the human disease. J Invest Dermatol, in press.
  10. ^ Center for Research on Inflammation of the Skin (CRIS). University of Lübeck, accessed on March 5, 2017 .
  11. ↑ DFG, Medical Review Board. In: www.dfg.de. March 1, 2017, accessed March 4, 2017 .
  12. ↑ Review Board 205 "Medicine" - Inflammation Research Section, term of office 2016-2019. DFG, accessed on March 4, 2017 .
  13. ↑ Cluster of Excellence Inflammation at Interfaces, full members. Cluster of Excellence in Inflammation Research, accessed on March 4, 2017 .
  14. ↑ GRK1727 - GRK "Modulation of Autoimmunity". University of Lübeck, accessed on March 5, 2017 .
  15. ↑ Clinical Research Group 303 “Pemphigoid Diseases - Molecular Mechanisms and their Therapeutic Influence”. University Medical Center Schleswig-Holstein, accessed on April 14, 2017 .
personal data
SURNAME Zillikens, Detlef
BRIEF DESCRIPTION German dermatologist and university professor
DATE OF BIRTH July 15, 1958
PLACE OF BIRTH Wesseling