Diacylglycerol-O-acyltransferases

Diacylglycerol- O -acyltransferases ( DGAT ) are a group of enzymes from the metabolism of lipids .

properties

Probably the best characterized enzymes of the group are DGAT1 and DGAT2 . DGAT are involved in the biosynthesis of triacylglycerides . They transfer an acyl group from acyl-CoA to diacylglycerol , as the final step in the biosynthesis of triacylglycerides. In contrast to DGAT1, DGAT2 is essential.

DGAT inhibitors are being studied for the treatment of obesity .

Individual evidence

↑ CL Yen, SJ Stone, S. Koliwad, C. Harris, RV Farese: Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. In: Journal of lipid research. Volume 49, Number 11, November 2008, pp. 2283-2301, doi : 10.1194 / jlr.R800018-JLR200 , PMID 18757836 , PMC 3837458 (free full text).
^ R. Naik, BW Obiang-Obounou, M. Kim, Y. Choi, HS Lee, K. Lee: Therapeutic strategies for metabolic diseases: Small-molecule diacylglycerol acyltransferase (DGAT) inhibitors. In: ChemMedChem. Volume 9, Number 11, November 2014, pp. 2410-2424, doi : 10.1002 / cmdc.201402069 , PMID 24954424 .

[1] CL Yen, SJ Stone, S. Koliwad, C. Harris, RV Farese: Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. In: Journal of lipid research. Volume 49, Number 11, November 2008, pp. 2283-2301, doi : 10.1194 / jlr.R800018-JLR200 , PMID 18757836 , PMC 3837458 (free full text).

[2] R. Naik, BW Obiang-Obounou, M. Kim, Y. Choi, HS Lee, K. Lee: Therapeutic strategies for metabolic diseases: Small-molecule diacylglycerol acyltransferase (DGAT) inhibitors. In: ChemMedChem. Volume 9, Number 11, November 2014, pp. 2410-2424, doi : 10.1002 / cmdc.201402069 , PMID 24954424 .