Diacylglycerol-O-acyltransferase 2
Diacylglycerol O-acyltransferase 2 | ||
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other names |
Acyl-CoA-retinol-O-acyltransferase, ARAT, retinol-O-acyltransferase |
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Properties of human protein | ||
Mass / length primary structure | 388 amino acids , 43,831 Da | |
Identifier | ||
External IDs | ||
Enzyme classification | ||
EC, category | 2.3.1.20 | |
Orthologue (human) | ||
Entrez | 84649 | |
Ensemble | ENSG00000062282 | |
UniProt | Q96PD7 | |
Refseq (mRNA) | NM_001253891.1 | |
Refseq (protein) | NP_001240820.1 | |
PubMed search |
84649
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Diacylglycerol- O -acyltransferase 2 ( DGAT2 ) is an enzyme from the metabolism of lipids .
properties
DGAT2 is an enzyme from the group of diacylglycerol-O-acyltransferases that is involved in the biosynthesis of triacylglycerides . It transfers an acyl group from acyl-CoA to diacylglycerol (as the last step in the biosynthesis of triacylglycerides) or retinol . In contrast to DGAT1 , DGAT2 is essential. GPAT2 is inhibited by niacin .
DGAT2 catalyzes the following reactions:
Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol
Acyl-CoA + retinol = CoA + retinyl ester
DGAT2 is involved in the development of fatty liver when the carbohydrate intake is too high .
Web links
Individual evidence
- ↑ VA Zammit: Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia. In: The Biochemical journal. Volume 451, Number 1, April 2013, pp. 1-12, doi : 10.1042 / BJ20121689 , PMID 23489367 .