Diacylglycerol-O-acyltransferase 1
| Diacylglycerol- O -acyltransferase 1 | ||
|---|---|---|
| other names |
ACAT-related gene product 1, Acyl-CoA retinol O-fatty acyltransferase |
|
| Properties of human protein | ||
| Mass / length primary structure | 488 amino acids , 55,278 Da | |
| Identifier | ||
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.3.1.20 | |
Diacylglycerol- O -acyltransferase 1 ( DGAT1 ) is an enzyme from the metabolism of lipids .
properties
DGAT1 is involved as an enzyme from the group of diacylglycerol-O-acyltransferases in the biosynthesis of triacylglycerides . It transfers an acyl group from acyl-CoA to diacylglycerol or retinol . In contrast to DGAT2 , DGAT1 is not essential. XP620 inhibits DGAT1 with an IC50 of 25.9 uM for retinol and 13.9 uM for palmitoyl-coenzyme A .
DGAT1 catalyzes the following reactions:
Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol
Acyl-CoA + retinol = CoA + retinyl ester
Inhibitors of DGAT1 be for the treatment of obesity studied.
Web links
Individual evidence
- ^ RJ DeVita, S. Pinto: Current status of the research and development of diacylglycerol O-acyltransferase 1 (DGAT1) inhibitors. In: Journal of medicinal chemistry. Volume 56, Number 24, December 2013, pp. 9820-9825, doi : 10.1021 / jm4007033 , PMID 23919406 .