Drosophila Insulin-like Peptides

Drosophila insulin-like peptides ( DILPs ) are a class of insect hormones that are used , among other things, to control blood sugar in invertebrates . These hormones , which consist of two peptide chains, are similar to insulin in vertebrates . In addition, they occupy a receptor (dInR) that is almost identical to the insulin receptor of higher vertebrates.

In fruit flies of the species Drosophila melanogaster seven DILP coding were genes found, the nematode Caenorhabditis elegans has the 38th

DILPs are made by small groups of cells in the insect brain . Among other things, they lower the blood sugar trehalose . Experimental destruction of these cell groups leads to development delay, short stature and diabetes mellitus in the animals , but also to an increase in lifespan.

Individual evidence

↑ J. Colombani, S. Raisin et al. a .: A nutrient sensor mechanism controls Drosophila growth. In: Cell. Volume 114, Number 6, September 2003, pp. 739-749. PMID 14505573 .
↑ Broughton SJ, Piper MD, Ikeya T, et al. : Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands . In: Proc. Natl. Acad. Sci. USA . 102, No. 8, February 2005, pp. 3105-10. doi : 10.1073 / pnas.0405775102 . PMID 15708981 . PMC 549445 (free full text).

[1] J. Colombani, S. Raisin et al. a .: A nutrient sensor mechanism controls Drosophila growth. In: Cell. Volume 114, Number 6, September 2003, pp. 739-749. PMID 14505573 .

[2] Broughton SJ, Piper MD, Ikeya T, et al. : Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands . In: Proc. Natl. Acad. Sci. USA . 102, No. 8, February 2005, pp. 3105-10. doi : 10.1073 / pnas.0405775102 . PMID 15708981 . PMC 549445 (free full text).