ERDRP-0519

Structural formula
General
Surname	ERDRP-0519
other names	2-methyl- N - {4 - [(2 S ) -2- (2-morpholin-4-ylethyl) piperidin-1-yl] sulfonylphenyl} -5- (trifluoromethyl) pyrazole-3-carboxamide
Molecular formula	C 23 H 30 F 3 N 5 O 4 S
External identifiers / databases
PubChem	57521469
Wikidata	Q18388961
properties
Molar mass	529.574 g mol −1
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

ERDRP-0519 (synonym Compound 16677 ) is an experimental antiviral agent with effectiveness against morbilliviruses .

properties

Among other things, ERDRP-0519 is effective against infections of the measles virus at a concentration of 35 to 145 nM . It inhibits viral RNA polymerase and thus viral replication . In animal experiments, ERDRP-0519 was effective for up to three days after the measles virus infection.

Individual evidence

↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ White LK, Yoon JJ, Lee JK, Sun A, Du Y, Fu H, Snyder JP, Plemper RK: Nonnucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity . In: Antimicrobial Agents and Chemotherapy . 51, No. 7, 2007, pp. 2293-303. doi : 10.1128 / AAC.00289-07 . PMID 17470652 . PMC 1913224 (free full text).
^ SA Krumm, D. Yan, ES Hovingh, TJ Evers, T. Enkirch, GP Reddy, A. Sun, MT Saindane, RF Arrendale, G. Painter, DC Liotta, MG Natchus, V. von Messling, RK Plemper: An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model. In: Science Translational Medicine . Volume 6, number 232, April 2014, p. 232ra52, doi : 10.1126 / scitranslmed.3008517 . PMID 24739760 . PMC 4080709 (free full text).

[NV-1] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[2] White LK, Yoon JJ, Lee JK, Sun A, Du Y, Fu H, Snyder JP, Plemper RK: Nonnucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity . In: Antimicrobial Agents and Chemotherapy . 51, No. 7, 2007, pp. 2293-303. doi : 10.1128 / AAC.00289-07 . PMID 17470652 . PMC 1913224 (free full text).

[3] SA Krumm, D. Yan, ES Hovingh, TJ Evers, T. Enkirch, GP Reddy, A. Sun, MT Saindane, RF Arrendale, G. Painter, DC Liotta, MG Natchus, V. von Messling, RK Plemper: An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model. In: Science Translational Medicine . Volume 6, number 232, April 2014, p. 232ra52, doi : 10.1126 / scitranslmed.3008517 . PMID 24739760 . PMC 4080709 (free full text).