Polygelin

Polygelin is a polymer made from urea and hydrolyzed gelatin with an average molar mass of 35,000 (5,000 to 50,000) Daltons .

Polygelin is excreted by the kidneys and has a plasma half-life of three to six hours. This is increased to up to 16 hours in patients with kidney damage. Adverse drug effects mainly due to the release of histamine (drop in blood pressure, bronchospasm and skin involvement such as urticaria ) were observed in 0.78% of the cases.

application

Polygelin is used in a 3.5% concentration as a colloidal plasma substitute (Haemaccel ^® or Emagel ^® ), but it is not suitable for preoperative acute normovolemic hemodilution (ANH).

In addition, it is or was present in various vaccines and other drugs as a stabilizer . Currently included is polygelin z. B. in Rabipur ^® , Rabivac ^® (vaccines against rabies ) and BCG medac (a drug for instillation into the bladder against bladder cancer ).

Individual evidence

^ MJ Davies: Polygeline. In: Developments in biological standardization. Volume 67, 1987, pp. 129-131, PMID 3609473 .
↑ M. Rehm, VH Orth, E. Weninger, M. Jacob, S. Mayer, H. Brechtelsbauer, U. Finsterer: Acute "normovoläme" hemodilution with 3.5% polygelin (Haemaccel) in a patient before Wertheim-Meigs- Surgery. In: The anesthesiologist. 50, 2001, p. 580, doi : 10.1007 / s001010100176 .

[1] MJ Davies: Polygeline. In: Developments in biological standardization. Volume 67, 1987, pp. 129-131, PMID 3609473 .

[2] M. Rehm, VH Orth, E. Weninger, M. Jacob, S. Mayer, H. Brechtelsbauer, U. Finsterer: Acute "normovoläme" hemodilution with 3.5% polygelin (Haemaccel) in a patient before Wertheim-Meigs- Surgery. In: The anesthesiologist. 50, 2001, p. 580, doi : 10.1007 / s001010100176 .