Emerin
| Emerin | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 254 amino acids | |
| Identifier | ||
| Gene name | EMD | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Mammals | |
Emerin is a mammal - protein . It is anchored in the inner membrane of the cell nucleus . This is made possible by a transmembrane domain. Emerin creates a connection between the lamina and the nuclear envelope.
If the emerin is not functional, the mechanical stability of the cell nucleus suffers. Especially in mechanically stressed tissue, such as B. muscle tissue, this leads to damage to the cell nucleus and z. B. Emery Dreifuss Muscular Dystrophy . This X-linked degenerative myopathy is caused by the mutated human emerin gene .
literature
- JM Jacque, M. Stevenson: The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity. In: Nature. 441 (7093), June 2006, pp. 581-582. doi: 10.1038 / 441581a . PMID 16738646 .
- Fiona L Wilkinson, James M Holaska, Zhayi Zhang, Aarti Sharma, Sushila Manilal, Ian Holt, Stefan Stamm, Katherine L Wilson, Glenn E Morris: Emerin interacts in vitro with the splicing-associated factor, YT521-B. In: Eur. J. Biochem. (Germany) 270 (11), June 2003, pp. 2459-2466. doi: 10.1046 / j.1432-1033.2003.03617.x . PMID 12755701 .
- Giovanna Lattanzi, Vittoria Cenni, Sandra Marmiroli, Cristina Capanni, Elisabetta Mattioli, Luciano Merlini, Stefano Squarzoni, Nadir Mario Maraldi: Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts. In: Biochem. Biophys. Res. Commun. (United States) 303 (3), April 2003, pp. 764-770. doi: 10.1016 / S0006-291X (03) 00415-7 . PMID 12670476 .
- M. Sakaki, H. Koike, N. Takahashi, N. Sasagawa, S. Tomioka, K. Arahata, S. Ishiura: Interaction between emerin and nuclear lamins. In: J. Biochem. (Japan) 129 (2), February 2001, pp. 321-327. doi: 10.1093 / oxfordjournals.jbchem.a002860 . PMID 11173535 .
- L. Clements, S. Manilal, DR Love, GE Morris: Direct interaction between emerin and lamin A. In: Biochem. Biophys. Res. Commun. (UNITED STATES) 267 (3), Jan 2000, pp. 709-714. doi: 10.1006 / bbrc.1999.2023 . PMID 10673356 .