Eosinophilic cationic protein
| Eosinophilic cationic protein | ||
|---|---|---|
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Existing structural data : 1DYT , 1H1H , 1QMT , 2KB5 , 2LVZ , 4A2O , 4A2Y , 4OWZ , 4OXB , 4OXF |
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| Properties of human protein | ||
| Mass / length primary structure | 133 amino acids | |
| Identifier | ||
| Gene name | RNASE3 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.1.27. , Nuclease | |
| Response type | hydrolysis | |
| Substrate | RNA | |
| Products | Degradation products | |
| Occurrence | ||
| Homology family | RNase 4 | |
| Parent taxon | Vertebrates | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 6037 | 503847 |
| Ensemble | ENSG00000169397 | ENSMUSG00000050766 |
| UniProt | P12724 | O35291 |
| Refseq (mRNA) | NM_002935 | NM_017389 |
| Refseq (protein) | NP_002926 | NP_059085 |
| Gene locus | Chr 14: 20.89 - 20.89 Mb | Chr 14: 51.2 - 51.2 Mb |
| PubMed search | 6037 |
503847
|
The eosinophil cationic protein (ECP) is an antibiotic and anthelmintic produced by the human body . It is selectively synthesized in eosinophil granulocytes . Along with EDN, it is one of the main components of the eosinophilic granules. Both proteins are ribonucleases of the RNase A superfamily . Similar RNAses are found in all vertebrates .
effect
ECP is secreted by the eosinophilic granulocytes into the surrounding tissue as part of inflammatory reactions and has a local cytotoxic effect on various bacteria and parasites , but also on the body's own cells, e.g. B. on the epithelium in the airways.
Medical importance
The eosinophils play an important role in the pathogenesis of bronchial asthma . There is a close correlation between the number of eosinophils and the ECP concentration. Since there is also a correlation between the ECP concentration in the blood and the extent of the severity of the asthma, this parameter can e.g. B. contribute to monitoring the progress of asthma therapy.
Individual evidence
- ^ A. Fiocchi, L. Terracciano, A. Martelli, F. Guerriero, L. Bernardo: The natural history of childhood-onset asthma. In: Allergy and Asthma Proceedings . Volume 27, Number 3, 2006 May-Jun, pp. 178-185, PMID 16913259 .