CCL11

from Wikipedia, the free encyclopedia
CCL11
CCL11
according to PDB  1EOT
other names
  • Chemokine (CC Motif) ligand 11
  • SCYA11
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 11 (Eotaxin)
  • Eosinophil Chemotactic Protein
  • Eotaxin-1

Existing structural data : 1EOT , 2EOT , 2MPM

Properties of human protein
Mass / length primary structure 97 amino acids, 10732 Da
Identifier
External IDs
Orthologue
human House mouse
Entrez 6356 20292
UniProt P51671 P48298
PubMed search 6356 20292

CCL11 ( English CC chemokine ligand 11 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL11 is involved in inflammatory processes. It is chemotactic for eosinophils . CCL11 binds to CCR2 , CCR3 and CCR5 .

Individual evidence

  1. Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ: Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. . In: J. Exp Med . 179, No. 3, 1994, pp. 881-7. doi : 10.1084 / jem.179.3.881 . PMID 7509365 . PMC 2191401 (free full text).
  2. Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR: Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils . In: J. Clin. Invest. . 97, No. 3, 1996, pp. 604-12. doi : 10.1172 / JCI118456 . PMID 8609214 . PMC 507095 (free full text).
  3. Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD: Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia . In: Nat. Med. . 2, No. 4, 1996, pp. 449-56. doi : 10.1038 / nm0496-449 . PMID 8597956 .
  4. ^ A b Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M: Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5 . In: Blood . 97, No. 7, 2001, pp. 1920-4. doi : 10.1182 / blood.V97.7.1920 . PMID 11264152 .
  5. Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O: Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3 . In: J. Biol. Chem. . 271, No. 13, 1996, pp. 7725-30. doi : 10.1074 / jbc.271.13.7725 . PMID 8631813 .