FGI-106
| Structural formula | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
||||||||||
| General | ||||||||||
| Surname | FGI-106 | |||||||||
| Molecular formula | C 28 H 38 N 6 | |||||||||
| External identifiers / databases | ||||||||||
|
||||||||||
| properties | ||||||||||
| Molar mass | 458.64 g mol −1 | |||||||||
| safety instructions | ||||||||||
|
||||||||||
| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | ||||||||||
FGI-106 is an experimental antiviral that is used against infections with various RNA viruses and belongs to the group of quinolines .
properties
FGI-106 is effective against Bunyaviridae ( Rift Valley Fever virus), Flaviviridae ( Dengue virus ) and Filoviridae such as Ebola virus by inhibiting the entry of the virus into cells ( entry inhibitor ).
literature
- E. De Clercq: A Cutting-Edge View on the Current State of Antiviral Drug Development. In: Medicinal Research Reviews . [Electronic publication before printing] March 2013, doi : 10.1002 / med.21281 , PMID 23495004 .
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ A. Basu, B. Li, DM Mills, RG Panchal, SC Cardinale, MM Butler, NP Peet, H. Majgier-Baranowska, JD Williams, I. Patel, DT Moir, S. Bavari, R. Ray, MR Farzan , L. Rong, TL Bowlin: Identification of a small-molecule entry inhibitor for filoviruses. In: Journal of virology. Volume 85, Number 7, April 2011, pp. 3106-3119, doi : 10.1128 / JVI.01456-10 , PMID 21270170 , PMC 3067866 (free full text).
- ^ E. De Clercq: Strategies for the treatment of dengue virus infections: a narrative account. In: Future Medicinal Chemistry . Volume 2, Number 4, April 2010, pp. 601-608, doi : 10.4155 / fmc.10.15 , PMID 21426010 .
- ↑ MJ Aman, MS Kinch, K. Warfield, T. Warren, A. Yunus, S. Enterlein, E. Stavale, P. Wang, S. Chang, Q. Tang, K. Porter, M. Goldblatt, S. Bavari : Development of a broad-spectrum antiviral with activity against Ebola virus. In: Antiviral Research . Volume 83, Number 3, September 2009, pp. 245-251, doi : 10.1016 / j.antiviral.2009.06.001 , PMID 19523489 .
- ↑ G. Ippolito, H. Feldmann, S. Lanini, F. Vairo, A. Di Caro, MR Capobianchi, E. Nicastri: Viral hemorrhagic fevers: advancing the level of treatment. In: BMC Medicine. Volume 10, 2012, p. 31, doi : 10.1186 / 1741-7015-10-31 , PMID 22458265 , PMC 3325866 (free full text).
