Fine needle biopsy

The fine needle biopsy (FNB), also called fine needle aspiration biopsy (FNAB) or fine needle aspiration (FNP), is a method for obtaining cells from an internal organ or tumor . Microscopic examinations are intended to clarify a local suspicion of cancer. The most common applications are fine needle biopsies of suspicious tumors in the thyroid gland , lungs , lymph nodes , masses in the abdomen, soft tissue tumors and prostate . It is particularly gentle and harmless. However, the punch biopsy is more accurate in some questions, for example in pretreated tissue or in the female breast .

Under manual control and without local anesthesia, a short, approx. 0.75 mm thin injection needle is inserted into suspicious lumps under the skin . For deeper lumps, longer needles are used specifically under ultrasound or X-ray control. By applying suction (negative pressure) with an attached syringe and fan-shaped movements of the needle, the amount of cells corresponding to a drop is sucked out, which can include several thousand cells from different regions of the tissue concerned. They are placed on glass slides and stained. The assessment is carried out by a pathologist .

In contrast to punch biopsy, fine needle biopsy is usually painless and hardly causes any complications (bleeding, infections). The spread of tumor cells through the fine needle biopsy only occurs in exceptional cases. Further examinations of the removed cells using DNA cytometry , fluorescence in situ hybridization (FisH) or immunocytochemistry (a method for identifying individual tumor cells that have been carried over) can further improve the diagnostic accuracy of the fine needle biopsy.

literature

Henryk A. Domanski: Atlas of Fine Needle Aspiration Cytology . Springer Science & Business Media, October 13, 2013, ISBN 978-1-4471-2446-7 , p. 25.

Individual evidence

^ A. Berner, M. Lund-Iversen, JM Nesland: Fine needle aspirations in oncology. In: Arkhiv patologii. Volume 73, Number 4, 2011 Jul-Aug, pp. 21-26, PMID 22164426 (review).

↑ E. Piaton: Cytology in the positive diagnosis and grading of prostatic cancers: which indications do remain at the time of automatic biopsies and endorectal echography?]. In: Bulletin du cancer. Volume 79, Number 1, 1992, pp. 67-80, PMID 1520954 .

↑ J. Thierauf, J. Lindemann u. a .: [Value of fine needle aspiration cytology and core needle biopsy in the head and neck region]. In: Laryngo-Rhino-Otology. Volume 94, number 5, May 2015, pp. 311-316, doi : 10.1055 / s-0034-1385890 , PMID 25255122 .

↑ PJ Westenend, AR Sever u. a .: A comparison of aspiration cytology and core needle biopsy in the evaluation of breast lesions. In: Cancer. Volume 93, Number 2, April 2001, pp. 146-150, PMID 11309781 .

^ Heinrich Iro, J. Zenk, V. Uttenweiler: Head and neck sonography: A guide to practice-related ultrasound examination. Chapter 6.4 "Fine needle biopsy" . Springer-Verlag, March 12, 2013, ISBN 978-3-642-57012-4 , pp. 114–116.

↑ Voravud et al .: Implantation metastasis of carcinoma after percutaneous fine-needle aspiration biopsy. Chest. 1992 Jul; 102 (1): 313-5. PMID 1623781 full text ( memento of the original from April 5, 2008 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2
↑ Domanski 2013, p. 25

[PMID22164426-1] A. Berner, M. Lund-Iversen, JM Nesland: Fine needle aspirations in oncology. In: Arkhiv patologii. Volume 73, Number 4, 2011 Jul-Aug, pp. 21-26, PMID 22164426 (review).

[PMID1520954-2] E. Piaton: Cytology in the positive diagnosis and grading of prostatic cancers: which indications do remain at the time of automatic biopsies and endorectal echography?]. In: Bulletin du cancer. Volume 79, Number 1, 1992, pp. 67-80, PMID 1520954 .

[PMID25255122-3] J. Thierauf, J. Lindemann u. a .: [Value of fine needle aspiration cytology and core needle biopsy in the head and neck region]. In: Laryngo-Rhino-Otology. Volume 94, number 5, May 2015, pp. 311-316, doi : 10.1055 / s-0034-1385890 , PMID 25255122 .

[PMID11309781-4] PJ Westenend, AR Sever u. a .: A comparison of aspiration cytology and core needle biopsy in the evaluation of breast lesions. In: Cancer. Volume 93, Number 2, April 2001, pp. 146-150, PMID 11309781 .

[IroZenk2013-5] Heinrich Iro, J. Zenk, V. Uttenweiler: Head and neck sonography: A guide to practice-related ultrasound examination. Chapter 6.4 "Fine needle biopsy" . Springer-Verlag, March 12, 2013, ISBN 978-3-642-57012-4 , pp. 114–116.