Fomivirsen

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Structural formula
Structure of fomivirsen
General
Non-proprietary name Fomivirsen
Molecular formula C 204 H 263 N 63 O 114 P 20 S 20
External identifiers / databases
CAS number
  • 144245-52-3
  • 160369-77-7 (fomivirsen sodium)
Wikidata Q1435627
Drug information
ATC code

S01 AD09

Drug class

Antiviral

properties
Molar mass 6682.4 g mol −1
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Fomivirsen is an antisense oligonucleotide and a drug which is used as an antiviral agent for the treatment of infections with the cytomegalovirus (CMV) in immunodeficiency , such as AIDS .

Fomivirsen is a 21mer antisense DNA phosphorothioate oligonucleotide (ISIS 2922) with a sequence complementary to mRNA , the major immediate-early (MIE) transcriptional unit of the human cytomegalovirus (CMV). The binding of the aRNA to the complementary mRNA blocks the translation of this viral mRNA and thus prevents the gene expression of the proteins of the IE2 region (IE2), IE86 and IE55.

Fomivirsen was the first antisense oligonucleotide to be approved by the FDA .

The commercial preparation Vitravene ® is not marketable .

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ Nucleotide sequence of ISIS 2922: 5'-GCGTTTGCTCTTCTTCTTGCG-3 '
  3. ↑ Anderson, KP et al. (1996): Inhibition of human cytomegalovirus immediate-early gene expression by an antisense oligonucleotide complementary to immediate-early RNA. In: Antimicrob. Agents. Chemother. Vol. 40, pp. 2004-2011. PMID 8878571 , PMC 163463 (free full text).
  4. ↑ ABDA database (as of December 4, 2009).