Fosmid

Fosmids are a class of genetic vectors , i.e. elements into which a segment of DNA of interest can be cloned and then introduced into bacteria . Fosmids are similar to cosmids , but in contrast to these, they are derived from the bacterial F-plasmid . Compared to most plasmids , fosmids can usually accommodate significantly longer strands of DNA, usually up to 45–50 kilobase pairs . Due to their size, there is usually only one copy of the fosmid per bacterial cell. Fosmids are therefore better suited for creating a gene library , but worse for replicating the inserted DNA. In practice, fosmids have become rare since the introduction of Bacterial Artificial Chromosomes (BAC).

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• Robert E. Farrell, Jr .: RNA Methodologies: Laboratory Guide for Isolation and Characterization . 4th edition. Academic Press, 2009, ISBN 978-0-08-088495-0 , pp. 678 .
• Fosmid on Pflanzenforschung.de