Frank L. Graham

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Frank L. Graham is a Canadian molecular biologist .

Life

Graham studied at the University of Manitoba (bachelor's degree) and the University of Toronto , where he received his master's degree and doctorate. In the early 1970s he was a postdoctoral fellow in Alex J. van der Eb's laboratory at the University of Leiden . There he was significantly involved in the development of the HEK cell line (HEK 293 T) and in the development of a transfection method (insertion of DNA into mammalian cells) with calcium phosphate, both of which were later widely used tools in genetic engineering and cell biology. He became a professor at McMaster University , where he has since retired and was a Distinguished University Professor.

He later dealt with gene therapy against cancer with the help of adenoviruses . Graham developed a variant of the HEK cell line for the production of adenovirus vectors as early as 1977 .

He is a Fellow of the Royal Society of Canada . In 1998 he was awarded the Robert L. Noble Prize .

Individual evidence

  1. ^ Entry by Graham at McMaster University ( Memento from November 5, 2013 in the Internet Archive )
  2. ↑ The HEK 293 cell line ( Memento from October 16, 2014 in the Internet Archive )
  3. ↑ Mary Hitt, Christina Addison, Frank L. Graham: Human Adenovirus Vectors for Gene Transfer into Mammalian Cells . In: Advances in Pharmacology . tape 40 , 1997, pp. 137-206 , doi : 10.1016 / S1054-3589 (08) 60140-4 .
  4. ↑ Adenoviral Vectors ( Memento from August 26, 2012 in the Internet Archive )
  5. ^ Robert L Noble Prize at cancer.ca; Retrieved April 25, 2011
personal data
SURNAME Graham, Frank L.
BRIEF DESCRIPTION Canadian molecular biologist
DATE OF BIRTH 20th century