Galactorrhea-Amenorrhea Syndrome

Classification according to ICD-10
E22.1	Hyperprolactinemia
O92.6	Galactorrhea
ICD-10 online (WHO version 2019)

The galactorrhea-amenorrhea syndrome ( English galactorrhea-amenorrhea syndrome) is a collective term for endocrine diseases with disturbance of milk production and lack of menstrual bleeding.

In addition to the postpartum form (after a birth), there is the nonpuerperal form (without a previous birth).

The latter is usually caused by a prolactin- producing tumor of the adenohypophysis , a pituitary adenoma . Rarer causes are:

Infiltrative processes of the hypothalamus or pituitary stalk

Medicines, especially psychotropic drugs

Acromegaly

Hypothyroidism

Clinical manifestations

Clinical manifestations are:

Hyperprolactinemia (Forbes-Albright syndrome or Ahumada-DelCastillo syndrome)
Chiari Frommel Syndrome

Individual evidence

^ PK Win, I. Popescu, R. Nicoloff: Unusual case presentation of lichen simplex chronicus, Hodgkin's lymphoma, and nonpuerperal hyperprolactinemia-galactorrhea. In: Endocrine practice: official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. Vol. 7, No. 5, 2001 Sep-Oct, pp. 388-391, ISSN 1530-891X . doi : 10.4158 / EP.7.5.388 . PMID 11585377 . (Review).
^ Roche Lexicon Medicine

[1] PK Win, I. Popescu, R. Nicoloff: Unusual case presentation of lichen simplex chronicus, Hodgkin's lymphoma, and nonpuerperal hyperprolactinemia-galactorrhea. In: Endocrine practice: official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. Vol. 7, No. 5, 2001 Sep-Oct, pp. 388-391, ISSN 1530-891X . doi : 10.4158 / EP.7.5.388 . PMID 11585377 . (Review).

[2] Roche Lexicon Medicine