Glycerol phosphate O-acyltransferases

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Glycerol phosphate-O-acyltransferases ( GPAT ) are a group of enzymes from the metabolism of lipids .

properties

Probably the best characterized GPAT is glycerol-3-phosphate-O-acyltransferase 3 (GPAT3). GPAT are involved in the biosynthesis of glycerolipids . They transfer an acyl group from acyl-CoA to the hydroxyl group of glycerol-3-phosphate .

Some GPAT also use acylated glycerol-3-phosphate as a substrate and are also acylglycerol-3-phosphate-O-acyltransferases (AGPAT).

Individual evidence

  1. ↑ J. Cao, JL Li, D. Li, JF Tobin, RE Gimeno: Molecular identification of microsomal acyl-CoA: glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis. In: Proceedings of the National Academy of Sciences . Volume 103, number 52, December 2006, pp. 19695-19700, doi : 10.1073 / pnas.0609140103 , PMID 17170135 , PMC 1702318 (free full text).
  2. ↑ K. Takeuchi, K. Reue: Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis. In: American Journal of Physiology - Endocrinology and Metabolism. Volume 296, Number 6, June 2009, pp. E1195 – E1209, doi : 10.1152 / ajpendo.90958.2008 , PMID 19336658 , PMC 2692402 (free full text).