Glycerol-3-phosphate-O-acyltransferase 3
| Glycerol-3-phosphate acyltransferase 3 | ||
|---|---|---|
| other names |
1-acyl-sn-glycerol-3-phosphate-O-acyltransferase 10, AGPAT 10 |
|
| Properties of human protein | ||
| Mass / length primary structure | 434 amino acids , 48,705 Da | |
| Identifier | ||
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.3.1.15 | |
| Orthologue (human) | ||
| Entrez | 84803 | |
| Ensemble | ENSG00000138678 | |
| UniProt | Q53EU6 | |
| Refseq (mRNA) | NM_001256421.1 | |
| Refseq (protein) | NP_001243350.1 | |
| PubMed search |
84803
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Glycerol-3-phosphate- O- acyltransferase 3 ( GPAT3 ) is an enzyme from the metabolism of lipids .
properties
As an enzyme from the group of glycerol phosphate-O-acyltransferases and acylglycerol-3-phosphate-O-acyltransferases, GPAT3 is involved in the biosynthesis of triacylglycerides . It transfers the acyl group from acyl-CoA to the hydroxy group at position 1 of glycerol-3-phosphate . It also transfers acyl groups to position 2 of lysophosphatidic acid (ie if position 1 has already been acylated beforehand). In GPAT3, the enzyme activity is increased after activation of the insulin receptor by phosphorylation of serine and threonine .
The GPAT3 catalyzes the following reactions: acyl-CoA + sn-glycerol-3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate
Acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate
In adipose tissue , the enzyme activity of GPAT3 is increased 60-fold when it differentiates into adipocytes . GPAT3 is probably the main enzyme for acyl transfer to glycerol-3-phosphate there.
Web links
Individual evidence
- ↑ J. Cao, JL Li, D. Li, JF Tobin, RE Gimeno: Molecular identification of microsomal acyl-CoA: glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis. In: Proceedings of the National Academy of Sciences . Volume 103, number 52, December 2006, pp. 19695-19700, doi : 10.1073 / pnas.0609140103 , PMID 17170135 , PMC 1702318 (free full text).
- ↑ a b c D. Shan, JL Li, L. Wu, D. Li, J. Hurov, JF Tobin, RE Gimeno, J. Cao: GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis. In: Journal of lipid research. Volume 51, number 7, July 2010, pp. 1971–1981, doi : 10.1194 / jlr.M006304 , PMID 20181984 , PMC 2882735 (free full text).