Godtfredsen syndrome
| Classification according to ICD-10 | |
|---|---|
| C11 | Malignant neoplasm of the nasopharynx |
| ICD-10 online (WHO version 2019) | |
The Godtfredsen syndrome is a characteristic complex of ophthalmic and neurological symptoms in the early stages of malignant tumors in the nasopharynx .
The disease belongs to the cavernous sinus syndromes and is similar to Jacod syndrome .
Synonyms are: cavernous sinonasopharyngeal tumor syndrome; English Godtfredsen's disease; Foix's syndrome II; Foix-Jefferson syndrome
The name refers to the first author of the first description from 1944 by the Danish ophthalmologist and radiologist Erik Godtfredsen .
Clinical manifestations
Clinical criteria are:
- unilateral (unilateral) facial pain, especially in the maxillary nerve
- Unilateral palsy of the abdomen , later concomitant tumor symptoms
- Unilateral oculomotor paralysis , ptosis , paralytic strabismus , double vision
- unilateral trochlear palsy
- Unilateral optic damage with progressive deterioration in visual acuity
- Horner syndrome or unilateral exophthalmos
root cause
It is based on an expansion of a tumor through the orbital fissure into the area of the orbit .
Differential diagnosis
The Jacod syndrome is to be distinguished .
literature
- L. Thapa, R. Paudel, P. Chhetri, P. Rana: Eye twist and tongue twist: a rare neurological syndrome. In: Case Reports. 2011, 2011, S. bcr0620114366, doi: 10.1136 / bcr.06.2011.4366 .
- JR Keane: Combined VIth and XIIth cranial nerve palsies: a clival syndrome. In: Neurology. Vol. 54, No. 7, April 2000, pp. 1540-1541, PMID 10751279 .
Individual evidence
- ↑ a b c d Bernfried Leiber (founder): The clinical syndromes. Syndromes, sequences and symptom complexes . Ed .: G. Burg, J. Kunze, D. Pongratz, PG Scheurlen, A. Schinzel, J. Spranger. 7., completely reworked. Edition. tape 2 : symptoms . Urban & Schwarzenberg, Munich et al. 1990, ISBN 3-541-01727-9 .
- ^ Who named it Godtfredsen's syndrome
- ^ E. Godtfredsen: Ophthalmo-neurological symptoms in connection with malignant nasopharyngeal tumors. A clinical study comprising 454 cases. In: The British journal of ophthalmology. Vol. 31, No. 2, February 1947, pp. 78-100, PMID 18170322 , PMC 510701 (free full text).
