Jacod syndrome

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Classification according to ICD-10
C11 Malignant neoplasm of the nasopharynx
ICD-10 online (WHO version 2019)

The Jacod syndrome is a complex disease with unilateral precipitation of the cranial nerves II-VI in the early stages of malignant tumors in the nasopharynx , which pass through the base of the skull in the direction of orbit grow. The disease belongs to the cavernous sinus syndrome and is similar to Godtfredsen syndrome .

Synonyms are: petrosphenoid syndrome; Negri-Jacod Syndrome; Syndrome of the middle cranial nerve group; Jacod Trias

The name refers to the first author of the first description from 1921, the French neurologist Maurice Jacod .

root cause

It is usually caused by nasopharyngeal carcinoma extending into the cavernous sinus with ophthalmoplegia , blindness, and trigeminal neuralgia .

Clinical manifestations

Clinical criteria are:

literature

  • K. Abdulkadir, S. Buket, A. Dilek, O. Munevver, A. Ayse: Otitis complicated by Jacod's syndrome with unusal facial nerve involvement: Case report and review of literature. In: JPMA. The Journal of the Pakistan Medical Association. Volume 65, No. 4, April 2015, pp. 429-431, PMID 25976583 .
  • M. Fukumoto, N. Tsuboi, N. Yoshimura, A. Kurohara, D. Yoshida, T. Inomata, S. Yoshida: Dual isotopic SPECT in malignant Jacod's syndrome. In: Clinical Nuclear Medicine. Vol. 23, No. 7, July 1998, pp. 437-440, PMID 9676948 .
  • JJ van Overbeeke: The Cavernous Sinus Syndrome: An Anatomical and Clinical Study. In: M. Samii (Ed.): Surgery of the Sellar Region and Paranasal Sinuses . Springer, 1991, pp. 484-489, ISBN 978-3-642-76452-3 (print) 978-3-642-76450-9 (online), doi : 10.1007 / 978-3-642-76450-9_77

Individual evidence

  1. ↑ a b Bernfried Leiber (founder): The clinical syndromes. Syndromes, sequences and symptom complexes . Ed .: G. Burg, J. Kunze, D. Pongratz, PG Scheurlen, A. Schinzel, J. Spranger. 7., completely reworked. Edition. tape 2 : symptoms . Urban & Schwarzenberg, Munich et al. 1990, ISBN 3-541-01727-9 .
  2. ^ Jacod syndrome .
  3. ^ M. Jacod: Sur la propagation intracrânienne des sarcomes de la trmpe d'Eustache, syndrome du carrefour pétrosphénoidal, paralysie de 2e, 3e, 4e, 5e, et 6e paires crâniennes. In: Revue Neurologique Paris, Volume 28, 1921, pp. 33-38