Hiroshi Maeda (medic)
Hiroshi Maeda ( Japanese 前 田 浩 , Maeda Hiroshi ; born December 22, 1938 in Shisō in Hyōgo Prefecture ) is a Japanese pharmacologist and chemist. It is known for the EPR effect .
Maeda studied at the University of Tōhoku with a bachelor's degree in 1962, at the University of California, Davis with a master's degree in 1964 and was awarded a doctorate in 1967 at Tohoku University. As a post-doctoral student, he was at the Sidney Farber Cancer Institute at Harvard University from 1967 to 1971 . In 1972 he also obtained a medical doctorate there. From 1971 to 1980 he was assistant professor at Kumamoto University and from 1980 professor. In 2004 he retired. Then he was at the Sōjō University in Kumamoto .
Together with Yasuhiro Matsumura from the National Cancer Research Center in Tokyo, he discovered the so-called EPR effect, the passive accumulation of macromolecules, fat globules and nanoparticles in tumor tissue. Both belong to the Thomson Reuters Citation Laureates .
Maeda developed the first polymer-conjugated drug (SMANCS) for cancer therapy, which is approved in Japan for chemotherapy against liver cancer . It is an application of the EPR effect.
He also did research on viral diseases.
He has received the Royal Pharmaceutical Society's Lifetime Achievement Award, the Princess Takamatsu Prize for Cancer Research, and the Tomizo Yoshida Prize, the Japanese Cancer Research Society's highest award.
In 1990 he was a Lichfield Lecturer at Radcliffe Medical School, Oxford.
Fonts
- SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy , Adv. Drug Deliv. Rev., Vol. 46, 2001, pp. 169-185, PMID 11259839 .
- with J. Wu, T. Sawa, Y. Matsumura, K. Hori: Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review , J Control Release, Volume 65, 2000, pp. 271-284, PMID 10699287 .
- with T. Sawa, T. Konno: Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS , J Control Release, Volume 74, 2001, pp. 47-61 , PMID 11489482 .
- with Y. Matsumura: A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs , Cancer Res., Volume 46, 1986, pp. 6387-6392
Web links
| personal data | |
|---|---|
| SURNAME | Maeda, Hiroshi |
| ALTERNATIVE NAMES | 前 田 浩 (Japanese) |
| BRIEF DESCRIPTION | Japanese pharmacologist and chemist |
| DATE OF BIRTH | December 22, 1938 |
| PLACE OF BIRTH | Shisō , Hyōgo prefecture |