Yasuhiro Matsumura

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Yasuhiro Matsumura ( Jap. 松村保広 , Matsumura Yasushiro * 20th January 1955 in Hitoyoshi in Kumamoto Prefecture ) is a Japanese physician ( oncology ). He and Hiroshi Maeda discovered the EPR effect in chemotherapy against cancer.

Matsumura studied medicine from 1975 at the University of Kumamoto with a doctorate in medicine (MD) in 1981. He then completed training as a specialist in the surgical department of the University Hospital in Kumamoto and Kyushu. From 1984 he studied microbiology in Kumamoto and became assistant professor in 1988. From 1989 he was a post-doctoral student at Mount Sinai Medical Center in New York City and at Radcliffe Hospital in Oxford. From 1994 he was a member of the National Cancer Center Hospital, where he became head of the medical department in 1999. From 2002 he headed the Investigative Treatment Division at the Research Center for Innovative Oncology .

Together with Hiroshi Maeda, he developed a chemotherapy with polymers against tumors based on the EPR effect (the specific accumulation of macromolecules, fat globules and other things in tumor tissue) discovered by both of them. Matsumura carried out the clinical studies. Both became Thomson Reuters Citation Laureates through publications .

Matsumura developed a special chemotherapy called Cancer Stromal Targeting Therapy (CAST) with cytotoxic immunoconjugates against fibrin . He also studies blood clotting caused by cancer and developed diagnostic methods for the early detection of cancer with the help of automated cytodiagnostics .

Fonts

  • with H. Maeda: A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs , Cancer Res., Volume 46, 1986, pp 6387-6392
  • with D. Tarin: DNA fingerprinting survey of various human tumors and their metastasis . Cancer Res., Vol. 52, 1992, pp. 2174-2179
  • with D. Tarin: Significance of CD44 gene products for cancer diagnosis and disease evaluation . Lancet, Volume 340, 1992, pp. 1053-1058
  • with M. Gotoh, K .Muro, Y. Yamada, K. Shirao, Y. Shimada, M. Okuwa, S. Matsumoto, Y. Miyata, H. Ohkura, K. Chin, S. Baba, T. Yamao, A Kannami, Y. Takamatsu, K. Ito, K. Takahashi: Phase I and Pharmacokinetic Study of MCC-465, a doxorubicin (DXR) encapsulated in PEG-immunoliposome, in patients with metastatic stomach cancer . Annals Oncology, Vol. 15, 2004, pp. 517-525
  • with H Matsushita, Y Moriya, T Akasu, S Fujita, S Yamamoto, S Onouchi, N Saito, M Sugito, M Ito, T Kozu, T Minowa, S Nomura, H Tsunoda, T Kakizoe: A new methodology for isolating colonocytes from naturally evacuated feces and its clinical application to colorectal cancer diagnosis . Gastroenterology, Vol. 129, 2005, pp. 1918-1927
  • Preclinical and clinical studies of NK012, an SN-38 incorporating polymeric micelles, which is designed based on EPR effect . Adv Drug Deliv Rev, Vol. 63, 2011, pp. 184-192
  • with Y Koga, M Yasunaga, A Takahashi, J Kuroda, Y Moriya, T Akasu, S Fujita, S Yamamoto, H Baba: MicroRNA Expression Profiling of Exfoliated Colonocytes Isolated from Feces for Colorectal Cancer Screening . Cancer Prev Res (Phila)., Vol. 3, 2010, pp. 1435-1442
  • with T Hamaguchi, T Doi, T Eguchi-Nakajima, K Kato, Y Yamada, Y Shimada, N Fuse, A Ohtsu, S Matsumoto, M Takanashi: Phase I Study of NK012, a Novel SN-38-Incorporating Micellar Nanoparticle , in Adult Patients with Solid Tumors. Clin Cancer Res., Vol. 16, 2010, pp. 5058-5066
  • with M Yasunaga, S Manabe, D Tarin: Cancer-stroma targeting therapy by cytotoxic immunoconjugate bound to the collagen 4 network in the tumor tissue . Bioconjug. Chem, Volume 22, 2011, pp. 1776-1783

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personal data
SURNAME Matsumura, Yasuhiro
ALTERNATIVE NAMES 松 村 保 広 (Japanese)
BRIEF DESCRIPTION Japanese medic (oncology)
DATE OF BIRTH January 20, 1955
PLACE OF BIRTH Hitoyoshi , Kumamoto Prefecture