Human Proteome Folding Project
| Human Proteome Folding Project | |
|---|---|
| Area: | biochemistry |
| Target: | Structure prediction of human proteins |
| Country: | United States |
| Platform: | BOINC |
| Website: | worldcommunitygrid.org/research/hpf2 |
| Project status | |
| Status: | completed |
| Start: | November 16, 2004 |
| The End: | June 25, 2013 |
The Human Proteome Folding Project was a World Community Grid project for distributed computing . The project was operated by New York University , the Institute of Systems Biology in Seattle and the University of Washington . The aim of this project was the de novo structure prediction of human proteins . The software of the Rosetta @ home project is used as the algorithm, which is considered to be very efficient due to the very good results in the CASP competition. The project was carried out in two phases in which medically important proteins are examined in more detail.
On July 10, 2007 it became known that the first malaria- relevant data set of proteins had been successfully calculated.
The project is based on the BOINC infrastructure. A separate client was previously used, but this has been discontinued. The infrastructure of the project was sponsored by IBM , but it is not a commercial project as all results are publicly available.
Publications
- L Malmstrom, M Riffle, CE Strauss, D Chivian, TN Davis, R Bonneau, D. Baker: Superfamily Assignments for the Yeast Proteome through Integration of Structure Prediction with the Gene Ontology. In: PLoS Biol . , 2007 Mar 20, 5 (4), p. E76.
- R Bonneau, MT Facciotti, DJ Reiss, AK Schmid, M Pan, A Kaur, V Thorsson, P Shannon, MH Johnson, JC Bare, W Longabaugh, M Vuthoori, K Whitehead, A Madar, L Suzuki, T Mori, DE Chang , o J Diruggier, CH Johnson, L Hood, NS. Baliga: A predictive model for transcriptional control of physiology in a free living cell. In: Cell , 2007 Dec 28, 131 (7), pp. 1354-1365, PMID 18160043 .
Web links
- Official Homepage (English)
- HUMAN PROTEOME FOLDING PROJECT - Information about the project ( Memento from November 7, 2005 in the Internet Archive )
Individual evidence
- ↑ End of the Human Proteome Folding - Phase 2 Project Communication on the end of the project on the WCG project page