ICI 118551
| Structural formula | |||||||||||||
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-1-((7-methyl-2,3-dihydro-1H-inden-4-yl)oxy)butan-2-ol_200.svg)
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| Simplified structural formula without stereochemistry | |||||||||||||
| General | |||||||||||||
| Surname | ICI 118551 | ||||||||||||
| other names |
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| Molecular formula | C 17 H 27 NO 2 | ||||||||||||
| Brief description |
White dust |
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| properties | |||||||||||||
| Molar mass | 277.4 g · mol -1 | ||||||||||||
| safety instructions | |||||||||||||
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | |||||||||||||
ICI 118551 is a β2-selective - adrenoceptor blockers from the group of beta blockers . ICI 118551 was developed by Imperial Chemical Industries , which was acquired by AkzoNobel in 2008 .
Extraction and presentation
ICI 118551 can be prepared starting from 7-methylindan-4-ol.
use
ICI 118551 is used in particular in experimental pharmacology. So far there is no therapeutic use. There is no drug approval .
Individual evidence
- ↑ Data sheet ICI 118,551 hydrochloride, ≥98% (HPLC), powder from Sigma-Aldrich , accessed on January 2, 2014 ( PDF ).
- ↑ Enzo Life Sciences: ICI-118,551-bml-ar104-Enzo Life Sciences , accessed Thursday January 2, 2014
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ Hillman KL, Doze VA, Porter JE: Functional characterization of the beta-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus PDF . In: The Journal of Pharmacology and Experimental Therapeutics . 314, No. 2, August 2005, pp. 561-7. doi : 10.1124 / jpet.105.084947 . PMID 15908513 .
- ↑ James R. Baker, J. Daniel Hothersall, Richard J. Fitzmaurice, Matthew Tucknott, Andy Vinter, Andrew Tinker and Stephen Caddick: An efficient asymmetric synthesis of the potent β-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity Abstract . In: Chem. Commun. tape 46 , 2010, p. 3953-3954 , doi : 10.1039 / C0CC00142B .
- ^ SR O'Donnell, JC Wanstall: Evidence that ICI 118, 551 is a potent, highly Beta 2-selective adrenoceptor antagonist and can be used to characterize Beta-adrenoceptor populations in tissues . In: Life Sci . 27, No. 8, August 1980, pp. 671-677. ISSN 0024-3205 . PMID 6106143 .
