Idiot
An idiotope is an epitope in the variable region of an antibody or a T cell receptor .
properties
An idiotope is part of the characteristic variable area ( idiotype ) of a certain antibody or T-cell receptor. Anti- idiotypic antibodies bind to an idiotope and can competitively inhibit binding between the antibody and the epitope in its antigen . In contrast to the idiotopes, the constant areas of antibodies or T-cell receptors are called allotopes . The hypothesis of the regulation of the antibody response by anti-idiotypic antibodies ( Network Hypothesis ) was put forward by Niels Jerne in 1974 .
literature
- Charles Janeway , et al .: Immunobiology . 6th ed. ISBN 0-8153-4101-6 . The 5th English edition is available online on the pages of the NCBI Bookshelf (online) .
Individual evidence
- ↑ Detlev Ganten, Klaus Ruckpaul: Molecular medical principles of rheumatic diseases. Springer-Verlag, 2013. ISBN 9783642558030 . Pp. 168-169. ( limited preview in Google Book search).