Immunophilins
| Immunophilins | ||
|---|---|---|
| Enzyme classification | ||
| EC, category | 5.2.1.8 , isomerase | |
| Response type | Rearrangement | |
| Substrate | Peptidyl proline | |
| Occurrence | ||
| Parent taxon | Vertebrates | |
In immunophilins is proteins , the animal inside as well as plant cells occur. So far, 7 human immunophilins are known. They can be found in numerous organs, with particularly high concentrations in the brain. Immunophilins are e.g. B. Cyclophilin and FKBP .
Tasks in the organism
- Immunophilins acquired particular importance in connection with the mechanism of action of the immunosuppressive drugs cyclosporine and tacrolimus , for which they function as intracellular receptors . The complex of immunophilin and immunosuppressant triggers a cascade of reactions that inhibit the reproduction of T cells and thus the immune response to antigens foreign to the body . The term immunophilin can also be derived from this function .
- Apparently independent of the above mechanism, immunophilins are also enzymes . As such, they catalyze the conversion of the cis - and trans - isomers of peptidyl-prolyl bonds in peptide and protein substrates.
Individual evidence
- ↑ CB Kang, Y. Hong, S. Dhe-Paganon, HS Yoon: FKBP family proteins: immunophilins with versatile biological functions. In: Neuro-Signals. Volume 16, Number 4, 2008, pp. 318-325, ISSN 1424-8638 . doi : 10.1159 / 000123041 . PMID 18635947 .
- ^ S. Barik: Immunophilins: for the love of proteins. In: Cellular and molecular life sciences: CMLS. Volume 63, Number 24, December 2006, pp. 2889-2900, ISSN 1420-682X . doi : 10.1007 / s00018-006-6215-3 . PMID 17075696 .