Inodilator
An inodilator (also inodilator ) is a pharmacologically active substance that both increases the force of contraction of the heart (positive inotropic ) and at the same time has a vasodilator ( vasodilator ) effect.
The effect is based on the inhibition of the enzyme phosphodiesterase-3 ( phosphodiesterase-3 inhibitors , e.g. milrinone , enoximon , amrinone ). In the case of substances from the group of calcium sensitizers, there is an additional increase in the sensitivity (sensitivity) of heart muscle cells to calcium ions ( levosimendan , pimobendan ).
Inodilators are very effective medicinal substances in the treatment of acute severe heart failure , but due to their considerable side effects they are not suitable for long-term therapy.
Individual evidence
- ^ A b E. Mutschler, G. Geisslinger, HK Kroemer, P. Ruth, M. Schäfer-Korting: drug effects. Textbook of pharmacology and toxicology. 9th edition. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart 2008, ISBN 3-80-471952-X , p. 584.
- ↑ Product information Simdax 2.5 mg / ml. Status: July 2009
- ↑ Entry on Pimobendan at Vetpharm, accessed on August 11, 2012.