Interferon-γ
| IFNG | ||
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| according to PDB 1FQ9 | ||
| other names |
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| Properties of human protein | ||
| Mass / length primary structure | 166 amino acids, 19348 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue | ||
| human | House mouse | |
| Entrez | 3458 | 15978 |
| UniProt | P01579 | P01580 |
| PubMed search | 3458 |
15978
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Interferon-γ is a cytokine from the interferon family .
properties
Interferon-γ is involved in inflammatory processes. IFNγ has antiviral, immunostimulatory and anti-tumor properties. After binding its heterodimeric receptor (from IFNGR1 and IFNGR2 ), it induces around 30 genes by activating the JAK-STAT signaling pathway . Besides interleukin-2, interferon-γ is the main activating cytokine for cytotoxic T cells . It activates macrophages and induces the formation of MHC-II . IFNγ is formed in the course of the innate immune response of NK cells and NK T cells and in the course of the adaptive immune response by both CD4 and CD8 positive T cells .
Interferon-γ can be determined experimentally, among other things, by an ELISPOT , an ELISA or by flow cytometry .
Individual evidence
- ↑ Schroder K, Hertzog PJ, Ravasi T, Hume DA: Interferon-gamma: an overview of signals, mechanisms and functions . In: J. Leukoc. Biol . 75, No. 2, February 2004, pp. 163-89. doi : 10.1189 / jlb.0603252 . PMID 14525967 .
- ↑ Entrez Gene: INFG .
- ↑ Schoenborn JR, Wilson CB: Regulation of interferon-gamma during innate and adaptive immune responses . In: Adv. Immunol. . 96, 2007, pp. 41-101. doi : 10.1016 / S0065-2776 (07) 96002-2 . PMID 17981204 .