Cathepsins
Cathepsins (also Kat (h) epsine from Greek καθεψειν - digest) are endoproteases that can be found in lysosomes , eosinophilic granulocytes and osteoclasts , for example , and cause hydrolytic degradation of the extracellular matrix and the basement membrane ( proteases are protein-splitting enzymes ). You are e.g. B. involved in the breakdown of cell organelles , such as overaged mitochondria or collagen-containing bone matrix. The cathepsins are probably also involved in angiogenesis , i.e. the formation of new blood vessels in the course of wound healing and invasive tumor growth .
Cathepsins can be proven to be an unfavorable prognostic marker in various tumors such as pancreatic cancer .
It was discovered by Richard Willstätter and Eugen Baumann in 1929 .
Table of Cathepsins
Inhibitors
Certain peptides cyclized via disulfide bridges have a potentially inhibitory effect on the human cathepsins L, B, H and K.
Individual evidence
- ↑ Marco Niedergethmann, Birgit Wostbrock, Jörg W. Sturm, Frank Willeke, Stefan Post, Ralf Hildenbrand: Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma. In: Pancreas , Volume 29, No. 3, October 2004, pp. 204-211.
- ^ Wolf-Dieter Müller-Jahncke, Chistoph Friedrich, Ulrich Meyer: Medicinal history . 2nd, revised and expanded edition. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart 2005, ISBN 978-3-8047-2113-5 , p. 114 .
- ↑ Tomaž Bratkovič, Mojca Lunder, Tatjana Popovič, Samo Kreft, Boris Turk, Borut Štrukelj, Uroš Urleb: Affinity selection to papain yields potent peptide inhibitors of cathepsins L, B, H, and K. In: Biochemical and Biophysical Research Communications , volume 332, No. 3, July 8, 2005, pp. 897-903, doi : 10.1016 / j.bbrc.2005.05.028 .
literature
- Sébastien Conus, Hans-Uwe Simon: Cathepsins: key modulators of cell death and inflammatory responses. In: Biochem. Pharmacol. Volume 76, No. 11, 2008, pp. 1374-1382, doi : 10.1016 / j.bcp.2008.07.041 .