Kupffer cell

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The Kupffer cells , also called Browicz-Kupffer cells or also often referred to as Kupffer star cells , are macrophages (scavenger cells) of the liver with an oval cell nucleus named after the discoverers Karl Wilhelm von Kupffer and Tadeusz Browicz . Only with the help of electron microscopy could these liver cells be differentiated into macrophages and fat-storing Ito cells .

Kupffer stellate cells in the liver sinusoids

The macrophages are located in the liver tissue on the inner wall of the liver sinusoids and differentiate from monocytes . For the portal vein - blood exogenous and endogenous substances (usually pollutants, bacteria and metabolic products, but also damaged and old erythrocytes ) and degrade them.

Individual evidence

  1. ↑ K. Wake: Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs. In: Int Rev Cytol. 66, 1980, pp. 303-353.
  2. ↑ U. Pfeifer: Liver fibrosis and liver cirrhosis . In: Helmut Denk, J. Düllmann (Ed.): Pathology of the liver and biliary tract . Springer, Berlin 2000, ISBN 3-540-65501-8 , pp. 747 .