Lacritin
| Lacritin | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 119 amino acids; 12.3 kD | |
| Precursor | (138 aa) | |
| Identifier | ||
| Gene name | LCRT | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Mammals | |
Lacritin is a protein in mammals that is secreted in humans by the acini of the lacrimal glands and itself increases tear secretion. Lacritin binds to collagen -IV, Fibronectin - and laminin -1 molecules of epithelial cells of the cornea and the triggers NFAT - and mTOR - signaling pathways of these cells. Lacritin can also trigger the sprouting of salivary gland cells in a dose-dependent manner . In blepharitis and two syndromes of dry eye , the Lacritinexpression is reduced.
Individual evidence
- ↑ Orthologist at OMA
- ↑ UniProt Q9GZZ8 .
- ↑ Lacritin. In: Online Mendelian Inheritance in Man . (English).
- ↑ McKown RL, Wang N, Raab RW, et al. : Lacritin and other new proteins of the lacrimal functional unit . In: Exp. Eye Res . 88, No. 5, May 2009, pp. 848-858. doi : 10.1016 / j.exer.2008.09.002 . PMID 18840430 .