Leemor Joshua Gate

Leemor Joshua-Tor (* 1961 in Israel ) is an Israeli molecular biologist and professor at the Cold Spring Harbor Laboratory .

Leemor Joshua-Tor graduated from Tel Aviv University with a bachelor's degree in chemistry and received a PhD in chemistry from the Weizmann Institute in Rehovot. As a post-doctoral student , she was at Caltech and then at the Cold Spring Harbor Laboratory, where she became an Associate Professor in 1999 and Professor in 2005. She is the dean of the Watson School of Biological Sciences. She has also been a researcher at the Howard Hughes Medical Institute since 2008 .

It deals with enzymes that are involved in RNA interference in the cell . In 2004 she and colleagues identified an argonaut protein (Argonaute 2) as a slicer of the messenger RNA in the RNA-induced silencing complex (RISC) and clarified the structure of the protein, initially for the prokaryote version. The structure of the human Argonaute-2 was also clarified in her laboratory in 2012.

She also looked at the protein called E1, which is found in papillomaviruses that cause cervical cancer and belongs to the helicases . She showed that several E1s form a complex that threads a strand of DNA through.

She received the Beckman Young Investigator Award and the Dorothy Crowfoot Hodgkin Award from the Protein Society. In 2017 she was elected to the American Academy of Arts and Sciences and the National Academy of Sciences .

Web links

• Joshua Gate Lab

Fonts

• with JJ Song, SK Smith, Gregory Hannon: Crystal structure of Argonaute and its implications for RISC slicer activity, Science, Volume 305, 2004, pp. 1434-1437, PMID 15284453 .

Individual evidence

1. ↑ Cold Spring Harbor Lab 2008, on the appointment as HHMI Investigator ( Memento of the original from July 5, 2016 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. 
2. ↑ Elkayam, Claus-Dieter Kuhn , A. Tocilj, AD Haase, EM Greene, Gregory Hannon, The structure of human argonaute-2 in complex with miR-20a, Cell, Volume 150, 2012, p. 223, PMID 22682761 .
3. ↑ Book of Members 1780 – present, Chapter J. (PDF; 354 ​​kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved December 27, 2017 (English).