Leucine aminopeptidase
| Leucine aminopeptidase | ||
|---|---|---|
|
||
| Cattle LAP | ||
| Properties of human protein | ||
| Mass / length primary structure | 519 amino acids | |
| Cofactor | 2 Zn 2+ | |
| Isoforms | 2 | |
| Identifier | ||
| Gene name | LAP3 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.4.11.1 , metalloprotease | |
| MEROPS | M17.001 | |
| Substrate | Cys-Gly | |
| Occurrence | ||
| Homology family | Leucyl aminopeptidase | |
| Parent taxon | Creature | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 51056 | 66988 |
| Ensemble | ENSG00000002549 | ENSMUSG00000039682 |
| UniProt | P28838 | Q9CPY7 |
| Refseq (mRNA) | NM_015907 | NM_024434 |
| Refseq (protein) | NP_056991 | NP_077754 |
| Gene locus | Chr 4: 17.58 - 17.61 Mb | Chr 5: 45.49 - 45.51 Mb |
| PubMed search | 51056 |
66988
|
The leucine aminopeptidase (LAP) is a enzyme of protein metabolism, the L-peptides and amino acid amides and Aminoarylamide N hydrolyzed -terminal. In humans , it occurs mainly in the intestines , kidneys , bile , gastric juice , saliva and plasma. The determination is made by measuring the conversion of L-leucine- p -nitranilide to p -nitraniline. Leucine aminopeptidase is rarely determined. However, it is well suited for differential diagnosis of increased AP . If the LAP is normal with increased AP, bone disease is likely. An increase in LAP is found above all in cholestasis , biliary tract infections, tumors and pregnancy. Decreased values can be observed in hypovolemia .
Normal values : women: 16 - 32 U / l, men: 11 - 35 U / l (determined from 1 ml serum)
Occurrence
The LAP is found in all living things; it has been detected in a large number of bacteria , protozoa , fungi , plants and animals .
Single receipts
- ↑ Brenda: EC 3.4.11.1
- ^ Pub Med: EC 3.4.11.1 .
