Menin
| Menin | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 615 amino acids | |
| Isoforms | Long, short, 3 | |
| Identifier | ||
| Gene name | MEN1 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Bilateral animals | |
Menin is a protein , which in the nucleus of vertebrates and insects on the DNA repair and development processes participates. The exact function is still unclear. Since a lack of menin can lead to tumors , the outdated term tumor suppressor is also used . In humans, menin is produced in many types of tissue . Meninmangel by mutations in MEN1 - gene (chromosome region 11q13) results in multiple endocrine neoplasia type. 1
In the case of DNA damage, menin occurs increasingly in a phosphorylated form. It can bind to different forms of DNA. Protein binding partners include FANCD2 and DBF4 as well as complexes with MLL. Menin is a participant in the MAPKKK signal cascade . By upregulating CDK inhibitors, menin can delay the G2 / M phase transition and reduce cyclin B2 expression. It takes part in developmental processes and gestational diabetes .
Individual evidence
- ↑ Orthologist at eggNOG
- ↑ a b UniProt O00255
- ↑ Wu T, Zhang X, Huang X et al .: Regulation of cyclin B2 expression and cell cycle G2 / m transition by menin. . In: J Biol Chem . 285, No. 24, June 2010, pp. 18291-18300. doi : 10.1074 / jbc.M110.106575 . PMID 20404349 .
- ↑ Balasubramanian D. & Scacheri PC .: Functional studies of menin through genetic manipulation of the Men1 homolog in mice. . In: Adv Exp Med Biol . 668, 2009, pp. 105-115. PMID 20175458 .