M-factor
The M-factor (also multiplication factor , factor M ) is used to classify mixtures with highly toxic components in the hazard classes acute or chronically hazardous to water . Substances that are classified as acutely or chronically hazardous to water under GHS or CLP are also given an M-factor for classification. The M-factor depends on the acute toxic effect on aquatic organisms ( L (E) C 50 ). When determining the classification using the summation method, substances are weighted by the M-factor.
factor
The M-factor is determined according to the following table:
Acute toxicity (CLP and GHS)
| L (E) C 50 value | Multiplication factor |
|---|---|
| 0.1 <L (E) C 50 ≤ 1 | 1 |
| 0.01 <L (E) C 50 ≤ 0.1 | 10 |
| 0.001 <L (E) C 50 ≤ 0.01 | 100 |
| 0.0001 <L (E) C 50 ≤ 0.001 | 1,000 |
| 0.00001 <L (E) C 50 ≤ 0.0001 | 10,000 |
| continue in factor 10 intervals | |
Chronic toxicity (GHS only)
| NOEC value | M-Factor NRD |
M-Factor RD |
|---|---|---|
| 0.01 <NOEC ≤ 0.1 | 1 | - |
| 0.001 <NOEC ≤ 0.01 | 10 | 1 |
| 0.0001 <NOEC ≤ 0.001 | 100 | 10 |
| 0.00001 <NOEC ≤ 0.0001 | 1,000 | 100 |
| 0.000001 <NOEC ≤ 0.00001 | 10,000 | 1,000 |
| continue in factor 10 intervals | ||
Examples
Selected M-factors of substances
- Bromoxynil : M = 10
- Triclosan : M = 100
- Azafenidin : M = 1000
- Mevinphos : M = 10000
Web links
- Regulation (EC) No. 1272/2008 (CLP regulation)
- Correction to Regulation (EC) No. 1272/2008
- Regulation (EU) No. 286/2011 amending Regulation 1272/2008
- Globally Harmonized System of Classification and Labeling of Chemicals (GHS) first edition 2003
- Globally Harmonized System of Classification and Labeling of Chemicals (GHS) First revised edition 2005
- Globally Harmonized System of Classification and Labeling of Chemicals (GHS) Second revised edition 2007
- Globally Harmonized System of Classification and Labeling of Chemicals (GHS) Third revised edition 2009
- Globally Harmonized System of Classification and Labeling of Chemicals (GHS) Fourth revised edition 2011