MAGE-A1

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MAGE-A1
MAGE-A1
according to PDB  3BO8
other names
  • Antigen MZ2-E
  • CT1.1

Existing structural data : 1W72 , 3BO8

Properties of human protein
Mass / length primary structure 34,342 Da / 309 amino acids
Identifier
Gene name MAGEA1
External IDs
Occurrence
Homology family HOG000231161

MAGE-A1 ( English melanoma antigen A3 ) is a human tumor antigen from the group of the cancer testis antigens .

properties

MAGE-A1 is 309 amino acids in length and 34,342 Da in mass . It has a poly serine tract from position 32 to 36. MAGE-A1 comes as a tumor antigen not in healthy cells before (except in immune privileged spermatocytes ), but often in different tumors expressed . It is therefore a target antigen in the development of cancer vaccines and cancer immunotherapies with adoptive cell transfer .

Individual evidence

  1. ↑ DK Krishnadas, F. Bai, KG Lucas: Cancer testis antigen and immunotherapy. In: ImmunoTargets and therapy. Volume 2, 2013, pp. 11-19, doi: 10.2147 / ITT.S35570 , PMID 27471684 , PMC 4928360 (free full text).
  2. ↑ M. Tagliamonte, A. Petrizzo, ML Tornesello, FM Buonaguro, L. Buonaguro: Antigen-specific vaccines for cancer treatment. In: Human vaccines & immunotherapeutics. Volume 10, number 11, 2014, pp. 3332–3346, doi: 10.4161 / 21645515.2014.973317 , PMID 25483639 , PMC 4514024 (free full text).