MAGIC syndrome

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Classification according to ICD-10
K13.70 Non-specific lesions of the oral mucosa
ICD-10 online (WHO version 2019)

The MAGIC syndrome is an acronym and stands for Mouth and genital ulcers with inflamed cartilage . It is a very rare autoimmune disease with an overlap between the clinical manifestations of Behçet's disease and polychondritis recidivans et atrophicans , with oral and genital ulcers and inflamed cartilage tissue . It is likely an immunological abnormality with elastin as a possible target antigen. So far, only 25 cases have been described worldwide (as of April 10, 2017).

Complications include hearing loss , pleurisy , gastrointestinal ulcers, vasculitis of the central nervous system (CNS) and deep vein thrombosis . Inflammatory aortitis is the most serious complication that can be life threatening and occurs in approximately 25% of reported cases.

Individual evidence

  1. ↑ RL Orme, JJ Nordlund u. a .: The MAGIC syndrome (mouth and genital ulcers with inflamed cartilage). In: Archives of dermatology. Volume 126, Number 7, July 1990, pp. 940-944, PMID 2360844 .
  2. ^ Peter Altmeyer: Therapielexikon Dermatologie und Allergologie . Springer-Verlag, July 2, 2013, ISBN 978-3-662-10498-9 , p. 587.
  3. ↑ a b Paul Curtiss, Gabriela Cobos, MAGIC Syndrome , visualDX, accessed November 14, 2017.