MCF-7
MCF-7 (Abbreviation for: Michigan Cancer Foundation - 7) is a breast cancer - cell line from a white (Caucasian) 69-year-old woman. The culture was created in 1970 from amputated breast tissue. Before MCF-7, all previous attempts to cultivate breast cell lines failed until Herbert Soule and his team established and presented this line in 1973.
The cell culture is very suitable for breast cancer studies and analyzes, since some properties of the breast epithelium have been preserved. So are z. B. these cells are estrogen- sensitive. They have estrogen receptors in the cytoplasm and respond to estrogen treatment with cell proliferation .
Individual evidence
- ↑ H. Soule, Vazquez J, Long A, Albert S, Brennan M: A human cell line from a pleural effusion derived from a breast carcinoma. In: Journal of the National Cancer Institute . 51 (5), 1973, 1409-1416; PMID 4357757 .
Literature (selection)
- Angela Siebel: Interactions between the signal transduction pathways of the estrogen receptors and the tyrosine kinase receptors using the example of the breast cancer cell line MCF-7 as the target of new treatment strategies. Univ., Diss., Lübeck 2008.
- Birte Andritzky: Studies on the role of the Fos family of transcription factors in the invasiveness of the breast cancer cell line MCF7. Univ., FB Medicine, Diss., Hamburg 2006.
- Friedemann Gaube: Gene expression profiling of extracts and natural substances: Investigations into the mode of action of "Cimicifuga racemosa" (L.) NUTT. and "Leuzea carthamoides" DC. in the human breast cancer cell line MCF-7. Univ., Diss., Jena 2006.
- Pablo Ibieta Hillerns: Interaction of phytoestrogens with rat uterine estrogen receptor, human sex hormone- binding globulin and human breast adenocarcinoma cells (MCF-7). Univ., Diss., Heidelberg 2005.
- Martina Lichtenberg: Modulation of the BMP-2 effect in the breast carcinoma cell line MCF-7. Univ., Diss., Jena 2004.