NCC-IT
NCC-IT cells are a model cell line ( pluripotent embryonic carcinoma ; teratocarcinoma ) that is used in biomedical research, including cancer research .
The name is derived from the National Cancer Institute in Tokyo , Japan.
NCC-IT cells were isolated from a mixed germ cell tumor in Japan in 1985 . They are capable of somatic and extraembryonic differentiation . The undifferentiated cells are to be regarded as an intermediate stage of seminoma and embryonic carcinoma . They can be differentiated with retinoic acid , are keratin- negative and positive for vimentin and placental alkaline phosphatase .
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- ^ S. Teshima, Y. Shimosato, S. Hirohashi, Y. Tome, I. Hayashi, H. Kanazawa, T. Kakizoe: Four new human germ cell tumor cell lines. In: Lab Invest. 59 (3), Sep 1988, pp. 328-336. PMID 2842544
- ^ I. Damjanov, B. Horvat, Z. Gibas: Retinoic acid-induced differentiation of the developmentally pluripotent human germ cell tumor-derived cell line, NCCIT. In: Lab Invest. 68 (2), Feb 1993, pp. 220-232.
- ↑ lgcstandards-atcc.org