M-CSF
| Monocyte Colony Stimulating Factor | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 522 AS ; 70 kDa | |
| Precursor | (554 AS) | |
| Isoforms | 3 | |
| Identifier | ||
| Gene name | CSF1 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Skull animals | |
M-CSF ( Macrophage colony-stimulating factor), also known as CSF-1 , is an endogenous protein from the group of cytokines . In particular, it causes mononuclear phagocytes , such as macrophages and monocytes , to mature from blood stem cells . At the molecular level, this effect is attributed to activation of the CSF1 receptor . All cells of mononuclear phagocytic origin carry this receptor , such as B. mononuclear phagocytic precursors, monocytes, macrophages, osteoclasts and microglia .
structure
M-CSF is a protein and is extracellularly in its active form as a disulfide-linked homodimer . It is believed to be formed from membrane-bound precursors through proteolysis .
Interactions with other proteins
An interaction of M-CSF with PIK3R2 has been demonstrated.
M-CSF produced locally in the vessel walls contributes to the development and course of arteriosclerosis .
M-CSF has also been linked to male fertility.
Individual evidence
- ↑ nlm.nih.gov (English)
- ↑ a b InterPro : IPR008001 Macrophage colony stimulating factor-1 (English)
- ^ A b Hahn, Falke, Kaufmann, Ullmann: Medical Microbiology and Infectiology . 5th edition Heidelberg 2004, ISBN 3-540-21971-4 .
- ↑ Piper: Internal Medicine . 1st edition Berlin 2006, ISBN 978-3-540-33725-6 .
- ↑ a b https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1435 (English)
- ↑ I Gout, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD: Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system . In: Biochem. J. . 288, No. 2, ENGLAND, December 1992, ISSN 0264-6021 , pp. 395-405. PMID 1334406 . PMC 1132024 (free full text).
- ↑ T. Rajavashisth, JH Qiao, S. Tripathi, J. Tripathi, N. Mishra, M. Hua, XP Wang, A. Loussararian, S. Clinton, P. Libby, A. Lusis: Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice. In: The Journal of clinical investigation. Volume 101, Number 12, June 1998, ISSN 0021-9738 , pp. 2702-2710, doi : 10.1172 / JCI119891 . PMID 9637704 , PMC 508861 (free full text).
- ↑ Paula E. Cohen, Liyin Zhu, Kayoko Nishimura, Jeffrey W. Pollard: Colony-Stimulating Factor 1 Regulation of Neuroendocrine Pathways that Control Gonadal Function in Mice . In: Endocrinology . 143, No. 4, US, April 2002, ISSN 0264-6021 , pp. 1413-1422. PMID 1334406 .