Myeloid suppressor cell
Myeloid suppressor cells ( MDSC engl. Myeloid-derived suppressor cells ) are a heterogeneous group of immature myeloid cells , which are capable of T-cell mediated immune responses to suppress. Normally ( health ) they regulate the renewal of the tissue and the immune response. In the case of long-term illnesses (autoimmune diseases, cancer, HIV), MDSC accumulate in the body and usually have a negative effect on healing.
In general, MDSC can be differentiated between PMN-MDSC (polymorphonuclear), M-MDSC (monocytic) and eMDSC (early). Due to their phenotype, PMN-MDSC resemble granulocytes and M-MDSC monocytes.
Since the severity of a long-term illness often correlates with the number of MDSC, MDSC could be used as a useful biomarker to monitor the (failure) success of a drug or, for example, chemotherapy. This can be done using flow cytometry.
In addition, various therapeutic approaches related to influencing the MDSCs are being pursued, for example to suppress the consequences of autoimmune diseases , carcinoma formation or transplant rejection .
Individual evidence
- ↑ V. Bronte, D. Gabrilovich: myeloid-derived suppressor cells , here online ; last accessed on Nov. 24, 2013