Manganese superoxide dismutases

Human tetrameric manganese superoxide dismutase 2 with manganese ions (purple spheres)

Manganese superoxide dismutases (also manganese / iron superoxide dismutases ) are enzymes and a subtype of superoxide dismutases .

properties

As superoxide dismutases manganese superoxide dismutases are in the detoxification of superoxide - radical (• O ₂^- involved). This leads to a disproportionation (synonym dismutation ) of the oxidation number of the two oxygen atoms . Manganese superoxide dismutases bind divalent or trivalent manganese or iron ions in their active center as cofactors . An example of manganese superoxide dismutases is the SOD2 in mitochondria .

Individual evidence

^ G. Bresciani, IB da Cruz, J. González-Gallego: Manganese superoxide dismutase and oxidative stress modulation. In: Advances in clinical chemistry. Volume 68, 2015, pp. 87-130, doi : 10.1016 / bs.acc.2014.11.001 , PMID 25858870 .
↑ GE Borgstahl, HE Parge, MJ Hickey, WF Beyer, RA Hallewell, JA Tainer: The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles. In: Cell. Volume 71, Number 1, October 1992, pp. 107-118, PMID 1394426 .

[1] G. Bresciani, IB da Cruz, J. González-Gallego: Manganese superoxide dismutase and oxidative stress modulation. In: Advances in clinical chemistry. Volume 68, 2015, pp. 87-130, doi : 10.1016 / bs.acc.2014.11.001 , PMID 25858870 .

[2] GE Borgstahl, HE Parge, MJ Hickey, WF Beyer, RA Hallewell, JA Tainer: The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles. In: Cell. Volume 71, Number 1, October 1992, pp. 107-118, PMID 1394426 .