Markus Rüegg

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Markus Rüegg (2011)

Markus Rüegg (born May 20, 1959 in Zurich ) is a Swiss neurobiologist and professor at the Biozentrum of the University of Basel .

Life

Markus Rüegg studied biochemistry at the University of Zurich and then did his doctorate in neurobiology . In 1989 he went to the Department of Neurobiology at Stanford University School of Medicine as a postdoctoral fellow .

In 1992 Markus Rüegg was appointed Assistant Professor at the Biozentrum of the University of Basel . Since 2004 he has been a full professor of neurobiology there.

Act

Rüegg researches the molecular processes that are important for the formation and function of the neuromuscular system. The investigations include the characterization of the extracellular and intracellular signaling pathways . Markus Rüegg succeeded in developing new therapeutic approaches for severe, genetic muscular dystrophy . Recently, his research group was able to show that the multi-protein complex mTORC1 is an important regulator of muscle growth and autophagy, a cellular self-cleaning process. These findings can help counteract the pathological breakdown of the muscles and identify new therapeutic approaches.

Awards

  • 2000 Robert Bing Prize from the Swiss Academy of Medical Sciences
  • 2013 Chairman of the Scientific Advisory Board of the Swiss Foundation for Research into Muscle Diseases (SSEM)
  • 2000–2007 council member of the Swiss Society for Neuroscience
  • 2014 Member of the Science Committee of the "European Neuromuscular Center" (ENMC)

Publications (selection)

Complete list of publications

  • MA Ruegg, KW Tsim, SE Horton, S. Kröger, G. Escher, EM Gensch, UJ McMahan: The agrin gene codes for a family of basal lamina proteins that differ in function and distribution. In: Neuron. Volume 8, 1992, pp. 691-699. PMID 1314621
  • J. Moll, P. Barzaghi, S. Lin, G. Bezakova, H. Lochmuller, E. Engvall, U. Muller, MA Ruegg: An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy. In: Nature. Volume 413, 2001, pp. 302-307. PMID 11565031
  • CF Bentzinger, K. Romanino, D. Cloetta, S. Lin, JB Mascarenhas, F. Oliveri, J. Xia, E. Casanova, CF Costa, M. Brink, F. Zorzato, MN Hall, MA Rüegg: Skeletal muscle- specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. In: Cell Metab. Volume 8, 2008, pp. 411-424. PMID 19046572
  • S. Meinen, S. Lin, R. Thurnherr, M. Erb, T. Meier, MA Ruegg: Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. In: EMBO Mol Med. Volume 3, 2011, pp. 465-479. PMID 21674808
  • P. Castets, S. Lin, N. Rion, S. Di Fulvio, K. Romanino, M. Guridi, S. Frank, LA Tintignac, M. Sinnreich, MA Ruegg: Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation -Induced Autophagy and Causes a Severe, Late-Onset Myopathy. In: Cell Metab. Volume 17, 2013, pp. 731-744. PMID 23602450

Web links

Individual evidence

  1. ^ Former lab member stanford.com, accessed July 8, 2014.
  2. ↑ Curriculum Vitae biozentrum.ch, accessed on July 8, 2014.
  3. ↑ If the cell cleaning fails, muscle weakness occurs myscience.ch, accessed on July 8, 2014.
  4. ^ Synopsis of the winners of the Robert Bing Prize ( memento from July 14, 2014 in the Internet Archive ) samw.ch, accessed on July 8, 2014.
  5. ↑ Scientific Advisory Board fsrmm.ch, accessed on July 8, 2014.
  6. ↑ ENMC Member and Partner Organizations enmc.org, accessed on July 8, 2014.
  7. ↑ Complete list of publications Biozentrum.unibas.ch. Retrieved July 8, 2014.
personal data
SURNAME Rüegg, Markus
ALTERNATIVE NAMES Rueegg, Markus A.
BRIEF DESCRIPTION Swiss neurobiologist and professor at the Biozentrum of the University of Basel, Switzerland
DATE OF BIRTH May 20, 1959
PLACE OF BIRTH Zurich