Ledderhose's disease

Classification according to ICD-10
M72.2	Fibromatosis of the plantar fascia (Ledderhose contracture)
ICD-10 online (WHO version 2019)

Plantar fibromatosis is a first time in 1894 by the German surgeon Georg Ledderhose described, benign and sometimes painful of connective tissue on the sole of the foot ( plantar - aponeurosis ) from the group of fibromatosis (see also Dupuytren's disease ). A progressive progression of the disease lasting several years is typical.

In Ledderhose's disease, knots and occasionally strands form in the plantar fascia underlying the skin of the sole. The lumps can become much larger than in Dupuytren's disease and ultimately affect the ability to walk. The disease can occur as a side effect of barbiturate anti-epileptic drugs such as phenobarbital or primidone, but also other drugs.

The operation for Ledderhose's disease is problematic because the feet are heavily stressed in everyday life. A rapid improvement after removal of the affected fascia has been reported in the case of cases . Treatment with soft X-rays shows good results - especially in the early stages . There are also attempts with shock wave therapies and the injection of collagenase , which loosens the hardening. The fibrosis perforation, which does not remove the growth but releases the contraction - at least for some time - plays a smaller role in Ledderhose's disease than in Dupuytren's disease, because in Ledderhose's disease the toes generally do not contract.

Ledderhose's disease I

Ledderhose's disease II

Web links

• dupuytren-online.de

Individual evidence

1. ↑ Georg Ledderhose: About tears of the plantar fascia. In: Langenbeck's archive for clinical surgery . tape 48 , 1894, pp. 853-856 .
2. ↑ D. Schmidt, G. Beck-Mannagetta, H. Sörensen: Plantar fibroma associated with phenobarbital treatment. In: J. Oxley, D. Janz, H. Meinardi (Eds.): Chronic Toxicity of Antiepileptic Drugs. Raven Press, New York 1983, pp. 133-145 .
3. ↑ A. Strzelczyk, H. Vogt, HM Hamer, G. Krämer: Continuous phenobarbital treatment leads to recurrent plantar fibromatosis. In: Epilepsia . tape 49 , 2008, p. 1965-1968 .
4. ^ W. Fröscher, F. Hoffmann: Dupuytren's contracture in patients with epilepsy: follow-up study. In: J. Oxley, D. Janz, H. Meinardi (Eds.): Chronic Toxicity of Antiepileptic Drugs . Raven Press, New York 1983, pp. 147-153 .
5. ↑ V. Vandersleyen, M. Grosber, S. Wilgenhof, J. De Kock, B. Neyns, J. Gutermuth: Vemurafenib-associated Dupuytren- and Ledderhose palmoplantar fibromatosis in metastatic melanoma patients . In: J Eur Acad Dermatol Venereol . tape 30 , no. 7 , 2016, p. 1133-1135 .
6. ^ BG Souza, GZ de Souza Júnior, RM Rodrigues, DS Dias, VM de Oliveira: Surgical Treatment of a Case of Ledderhose's Disease: A Safe Plantar Approach to Subtotal Fasciectomy . In: Case Rep Orthop . tape 2015 , 2015, p. 509732 .
7. ^ S. Grenfell, M. Borg: Radiotherapy in fascial fibromatosis: a case series, literature review and considerations for treatment of early-stage disease. In: J Med Imaging Radiat Oncol . tape 58 , no. 5 , 2014, p. 641-647 .
8. ↑ K. Knobloch, PM Vogt: High-energy focussed extracorporeal shockwave therapy reduces pain in plantar fibromatosis (Ledderhose's disease) . In: BMC Res Notes . tape 5 , 2012, p. 542 .
9. ↑ ZS Hammoudeh: Collagenase Clostridium histolyticum injection for plantar fibromatosis (Ledderhose disease). In: Plast Reconstr Surg . tape 134 , no. 3 , 2014, p. 497e-498e .

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !