Muhammad Nadeem gained his first international experience at the Asian Indoor Championships in Tehran in 2018 , where he was eliminated over 400 meters with 49.94 seconds in the lead. In August he took part in the Asian Games in Jakarta for the first time and was eighth in the relay in 3: 08.87 min and was eliminated from the individual competition in 48.97 s in the semi-finals. The following year he won the South Asian Games in Kathmandu in 14.30 s in the 110-meter hurdles .
In 2018 Nadeem became Pakistani champion with the 4 x 400 meter relay.