Muir Torre Syndrome
Classification according to ICD-10 | |
---|---|
C18.9 | Malignant neoplasm: colon, unspecified |
ICD-10 online (WHO version 2019) |
The Muir-Torre syndrome is a variant of the hereditary non-polypous colorectal carcinoma ( Lynch syndrome ), in which additional skin symptoms can be observed.
First described by Muir et al. 1967 and Torre 1968, in addition to carcinomas, urothelial and endometrial carcinomas , which are mainly located in the right colon , multiple benign and malignant sebum tumors and keratoacanthomas of the skin also occur.
The causes include mutations in genes that code for DNA mismatch repair proteins .
literature
- Otto Braun-Falco , Gerd Plewig, Helmut H. Wolff: Dermatology and Venereology . Springer Verlag, Berlin / Heidelberg 2005, ISBN 3-540-40525-9 .
- H. Renz-Polster , J. Braun: Basic textbook internal medicine . Urban & Fischer Verlag, Munich / Jena 2001, ISBN 3-437-41051-2 .
- EG Muir, AJ Bell, KA Barlow: Multiple primary carcinomata of the colon, duodenum, and larynx associated with kerato-acanthomata of the face. In: Br J Surg . 1967 Mar; 54 (3), pp. 191-195. PMID 6020987
- D. Torre: Multiple sebaceous tumors. In: Arch Dermatol. 1968 Nov; 98 (5), pp. 549-551. PMID 5684233
Web links
- Muir Torre Syndrome. In: Online Mendelian Inheritance in Man . (English)